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Wdr13 WD repeat domain 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317370, updated on 13-Apr-2024

Summary

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Official Symbol
Wdr13provided by RGD
Official Full Name
WD repeat domain 13provided by RGD
Primary source
RGD:1560982
See related
Ensembl:ENSRNOG00000039587 AllianceGenome:RGD:1560982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560982
Summary
Predicted to enable promoter-specific chromatin binding activity. Predicted to act upstream of or within negative regulation of type B pancreatic cell proliferation. Predicted to be located in centriolar satellite; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Orthologous to human WDR13 (WD repeat domain 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 249.0), Heart (RPKM 175.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wdr13 in Genome Data Viewer
Location:
Xq12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17034779..17045682)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14362484..14373727)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15112663..15123825)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 25 Neighboring gene RNA binding motif protein 3 Neighboring gene U6 spliceosomal RNA Neighboring gene WASP actin nucleation promoting factor Neighboring gene SUV39H1 histone lysine methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lack of Wdr13 gene in mice leads to enhanced pancreatic beta cell proliferation, hyperinsulinemia and mild obesity. Singh VP, et al. PLoS One, 2012. PMID 22715406, Free PMC Article
  2. Seven cDNAs enriched following hippocampal lesion: possible roles in neuronal responses to injury. Price M, et al. Brain Res Mol Brain Res, 2003 Sep 10. PMID 14499481
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of type B pancreatic cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108247.3 → NP_001101717.1  WD repeat-containing protein 13 isoform 1

    See identical proteins and their annotated locations for NP_001101717.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    B2RZ63, G3V6Q3
    Conserved Domains (2) summary
    COG2319
    Location:73 → 393
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:129 → 165
    7WD40; WD40 repeat [structural motif]

  2. NM_001398749.1 → NP_001385678.1  WD repeat-containing protein 13 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A6KP51
    Related
    ENSRNOP00000007464.7, ENSRNOT00000007464.8
    Conserved Domains (2) summary
    COG2319
    Location:165 → 485
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:221 → 257
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    17034779..17045682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099770.2 → XP_038955698.1  WD repeat-containing protein 13 isoform X2

    UniProtKB/TrEMBL
    B2RZ63, G3V6Q3
    Conserved Domains (2) summary
    COG2319
    Location:73 → 393
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:129 → 165
    7WD40; WD40 repeat [structural motif]

  2. XM_039099769.2 → XP_038955697.1  WD repeat-containing protein 13 isoform X1

    UniProtKB/TrEMBL
    G3V6Q3
    Conserved Domains (2) summary
    COG2319
    Location:165 → 485
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:221 → 257
    7WD40; WD40 repeat [structural motif]

  3. XM_063280050.1 → XP_063136120.1  WD repeat-containing protein 13 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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