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Nhs NHS actin remodeling regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 317494, updated on 13-Apr-2024

Summary

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Official Symbol
Nhsprovided by RGD
Official Full Name
NHS actin remodeling regulatorprovided by RGD
Primary source
RGD:1561818
See related
Ensembl:ENSRNOG00000030759 AllianceGenome:RGD:1561818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561818
Summary
Predicted to be involved in cell differentiation and lens development in camera-type eye. Predicted to be located in Golgi apparatus; cell junction; and nuclear body. Human ortholog(s) of this gene implicated in Nance-Horan syndrome and cataract 40. Orthologous to human NHS (NHS actin remodeling regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 57.3), Testes (RPKM 12.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nhs in Genome Data Viewer
Location:
Xq14
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (36185067..36524711)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (32553300..32892961)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (34312102..34675912)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene similar to ferritin heavy polypeptide-like 17 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 23 Neighboring gene U6 spliceosomal RNA Neighboring gene Scm polycomb group protein like 1 Neighboring gene prohibitin 1 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. New mutations in the NHS gene in Nance-Horan Syndrome families from the Netherlands. Florijn RJ, et al. Eur J Hum Genet, 2006 Sep. PMID 16736028
  2. Lens development in a dominant X-linked congenital cataract of the mouse. Grimes PA, et al. Exp Eye Res, 1993 Nov. PMID 8282045
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in lens development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lens development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
actin remodeling regulator NHS
Names
Nance-Horan syndrome (congenital cataracts and dental anomalies)
Nance-Horan syndrome protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191733.1 → NP_001178662.1  actin remodeling regulator NHS isoform 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    F1LU76
    Related
    ENSRNOP00000039704.6, ENSRNOT00000041924.6
    Conserved Domains (1) summary
    pfam15273
    Location:417 → 1037
    NHS; NHS-like

  2. NM_001414726.1 → NP_001401655.1  actin remodeling regulator NHS isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A0G2JXJ0
    Related
    ENSRNOP00000070291.2, ENSRNOT00000091746.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    36185067..36524711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008773173.4 → XP_008771395.1  actin remodeling regulator NHS isoform X2

    Conserved Domains (1) summary
    pfam15273
    Location:263 → 883
    NHS; NHS-like

  2. XM_017602085.3 → XP_017457574.1  actin remodeling regulator NHS isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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