Mcf2 MCF.2 cell line derived transforming sequence [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mcf2provided by RGD
Full Name: MCF.2 cell line derived transforming sequenceprovided by RGD
Primary source: RGD:1566098
See related: Ensembl:ENSRNOG00000003435 AllianceGenome:RGD:1566098
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566098
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in dendrite development. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be active in cytoplasm. Orthologous to human MCF2 (MCF.2 cell line derived transforming sequence). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 10.6), Testes (RPKM 9.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq36

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (143444510..143550839, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (138414077..138514828, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (143159071..143292467, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that polyamines regulate the activation of Dbl, a membrane-proximal process upstream of Rac1, to regulate migration of intestinal epithelial cells.
Title: Activation of Dbl restores migration in polyamine-depleted intestinal epithelial cells via Rho-GTPases.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendrite development	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extrinsic component of membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proto-oncogene DBL

Names: mcf.2 transforming sequence; proto-oncogene DBL-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.