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Nt5dc1 5'-nucleotidase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 319638, updated on 5-Mar-2024

Summary

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Official Symbol
Nt5dc1provided by MGI
Official Full Name
5'-nucleotidase domain containing 1provided by MGI
Primary source
MGI:MGI:2442446
See related
Ensembl:ENSMUSG00000039480 AllianceGenome:MGI:2442446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nt5c2l1; 6030401B09Rik
Summary
Predicted to enable 5'-nucleotidase activity. Orthologous to human NT5DC1 (5'-nucleotidase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 4.1), CNS E14 (RPKM 3.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B1; 10 18.85 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (34179605..34294585, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (34303609..34418589, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26564 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:34001757-34001940 Neighboring gene STARR-positive B cell enhancer ABC_E3882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:34017128-34017331 Neighboring gene testis-specific protein, Y-encoded-like 1 Neighboring gene TSPY-like 4 Neighboring gene STARR-seq mESC enhancer starr_26275 Neighboring gene collagen, type X, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_26277 Neighboring gene fyn-related kinase Neighboring gene STARR-seq mESC enhancer starr_26278 Neighboring gene STARR-seq mESC enhancer starr_26279 Neighboring gene STARR-seq mESC enhancer starr_26280 Neighboring gene CWC22 spliceosome-associated protein homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure of pyrimidine 5'-nucleotidase type 1. Insight into mechanism of action and inhibition during lead poisoning. Bitto E, et al. J Biol Chem, 2006 Jul 21. PMID 16672222
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibited by lead which binds at the active site and my inhibit lead poisoning.
    Title: Structure of pyrimidine 5'-nucleotidase type 1. Insight into mechanism of action and inhibition during lead poisoning.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107414

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
5'-nucleotidase domain-containing protein 1
Names
5'-nucleotidase, cytosolic II-like 1
cytosolic 5'-nucleotidase II-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347463.1 → NP_001334392.1  5'-nucleotidase domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning results in translation initiation at the downstream start codon to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK049656, BB618670, BC098476
    UniProtKB/Swiss-Prot
    Q8C5P5

  2. NM_176968.5 → NP_795942.2  5'-nucleotidase domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_795942.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK145666, BB618670, BC098476
    Consensus CDS
    CCDS23779.1
    UniProtKB/Swiss-Prot
    Q3TAL3, Q3TPT8, Q3TTI3, Q3UL73, Q4G0D1, Q8C5P5
    UniProtKB/TrEMBL
    Q05AG7
    Related
    ENSMUSP00000047126.8, ENSMUST00000047885.14
    Conserved Domains (1) summary
    cl17687
    Location:11 → 347
    5_nucleotid; 5' nucleotidase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    34179605..34294585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512764.4 → XP_006512827.1  5'-nucleotidase domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    E9QN01
    Related
    ENSMUSP00000097553.4, ENSMUST00000099973.4
    Conserved Domains (1) summary
    cl21460
    Location:7 → 187
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C5P5.2 GenPept UniProtKB/Swiss-Prot:Q8C5P5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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