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Tmcc3 transmembrane and coiled coil domains 3 [ Mus musculus (house mouse) ]

Gene ID: 319880, updated on 30-Apr-2024

Summary

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Official Symbol
Tmcc3provided by MGI
Official Full Name
transmembrane and coiled coil domains 3provided by MGI
Primary source
MGI:MGI:2442900
See related
Ensembl:ENSMUSG00000020023 AllianceGenome:MGI:2442900
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmcc1; Gm1556; A230066D03Rik; C630016B22Rik
Summary
Predicted to enable 14-3-3 protein binding activity and identical protein binding activity. Predicted to be located in endoplasmic reticulum. Predicted to be active in endomembrane system. Is expressed in several structures, including diencephalon; embryo mesenchyme; epithelium; genitourinary system; and trigeminal ganglion. Orthologous to human TMCC3 (transmembrane and coiled-coil domain family 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 15.1), colon adult (RPKM 12.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Tmcc3 in Genome Data Viewer
Location:
10 C2; 10 48.88 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (94147544..94426816)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (94311682..94590954)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93697972-93698081 Neighboring gene predicted gene, 32749 Neighboring gene STARR-seq mESC enhancer starr_27596 Neighboring gene predicted gene 4792 Neighboring gene STARR-positive B cell enhancer ABC_E5170 Neighboring gene STARR-positive B cell enhancer ABC_E6905 Neighboring gene STARR-positive B cell enhancer ABC_E6906 Neighboring gene STARR-positive B cell enhancer mm9_chr10:93889083-93889384 Neighboring gene STARR-seq mESC enhancer starr_27599 Neighboring gene predicted gene, 32827 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93986454-93986871 Neighboring gene predicted gene, 40743 Neighboring gene STARR-positive B cell enhancer ABC_E6908 Neighboring gene STARR-seq mESC enhancer starr_27602 Neighboring gene VISTA enhancer mm280 Neighboring gene STARR-seq mESC enhancer starr_27603 Neighboring gene STARR-positive B cell enhancer ABC_E8361 Neighboring gene microRNA 7211 Neighboring gene STARR-positive B cell enhancer ABC_E10637 Neighboring gene predicted gene, 32898 Neighboring gene predicted gene, 48658

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression and characterization of transmembrane and coiled-coil domain family 3. Sohn WJ, et al. BMB Rep, 2016 Nov. PMID 27697108, Free PMC Article
  2. A genomic atlas of mouse hypothalamic development. Shimogori T, et al. Nat Neurosci, 2010 Jun. PMID 20436479, Free PMC Article
  3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC30586

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane and coiled-coil domain protein 3
Names
transmembrane and coiled coil domains 1
transmembrane and coiled-coil domains protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168684.1 → NP_001162155.1  transmembrane and coiled-coil domain protein 3 isoform b

    See identical proteins and their annotated locations for NP_001162155.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3 4 and 6 encode the same isoform (b).
    Source sequence(s)
    AC165338, AK132545
    Consensus CDS
    CCDS48675.1
    UniProtKB/TrEMBL
    Q8C538
    Related
    ENSMUSP00000113122.2, ENSMUST00000121471.8
    Conserved Domains (1) summary
    pfam10267
    Location:34 → 432
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  2. NM_001359760.1 → NP_001346689.1  transmembrane and coiled-coil domain protein 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3 4 and 6 encode the same isoform (b).
    Source sequence(s)
    AK132545, BY122966, DV644958
    Consensus CDS
    CCDS48675.1
    UniProtKB/TrEMBL
    Q8C538
    Conserved Domains (1) summary
    pfam10267
    Location:34 → 432
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  3. NM_001359761.1 → NP_001346690.1  transmembrane and coiled-coil domain protein 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3 4 and 6 encode the same isoform (b).
    Source sequence(s)
    AC133210, AK079611, AK132545, BY122966, DV644958
    Consensus CDS
    CCDS48675.1
    UniProtKB/TrEMBL
    Q8C538
    Related
    ENSMUSP00000112669.2, ENSMUST00000117460.8
    Conserved Domains (1) summary
    pfam10267
    Location:34 → 432
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  4. NM_001359762.1 → NP_001346691.1  transmembrane and coiled-coil domain protein 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC133210, AK038827, AK132545, BY122966, BY130399, DV644958
    UniProtKB/TrEMBL
    Q8C440
    Conserved Domains (1) summary
    pfam10267
    Location:49 → 447
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  5. NM_172051.3 → NP_742048.2  transmembrane and coiled-coil domain protein 3 isoform a

    See identical proteins and their annotated locations for NP_742048.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK132545, BB619673
    Consensus CDS
    CCDS24134.1
    UniProtKB/Swiss-Prot
    Q501N6, Q8R310
    UniProtKB/TrEMBL
    Q8C440
    Related
    ENSMUSP00000063264.6, ENSMUST00000065060.12
    Conserved Domains (1) summary
    pfam10267
    Location:69 → 463
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  6. NM_177026.1 → NP_796000.1  transmembrane and coiled-coil domain protein 3 isoform b

    See identical proteins and their annotated locations for NP_796000.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3 4 and 6 encode the same isoform (b).
    Source sequence(s)
    AK132545, BY145366
    Consensus CDS
    CCDS48675.1
    UniProtKB/TrEMBL
    Q8C538
    Related
    ENSMUSP00000112401.2, ENSMUST00000117929.2
    Conserved Domains (1) summary
    pfam10267
    Location:34 → 432
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    94147544..94426816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245121.1 → XP_030100981.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    Q8C440
    Conserved Domains (1) summary
    pfam10267
    Location:49 → 447
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  2. XM_036155815.1 → XP_036011708.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    Q8C440
    Conserved Domains (1) summary
    pfam10267
    Location:49 → 447
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  3. XM_011243475.4 → XP_011241777.1  transmembrane and coiled-coil domain protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011241777.1

    UniProtKB/TrEMBL
    Q8C440
    Conserved Domains (1) summary
    pfam10267
    Location:49 → 447
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  4. XM_036155816.1 → XP_036011709.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    Q8C440
    Conserved Domains (1) summary
    pfam10267
    Location:49 → 447
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  5. XM_030245122.1 → XP_030100982.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    Q8C440
    Conserved Domains (1) summary
    pfam10267
    Location:49 → 447
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  6. XM_036155814.1 → XP_036011707.1  transmembrane and coiled-coil domain protein 3 isoform X1

    UniProtKB/TrEMBL
    Q8C440
    Conserved Domains (1) summary
    pfam10267
    Location:65 → 504
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  7. XM_006513754.5 → XP_006513817.1  transmembrane and coiled-coil domain protein 3 isoform X3

    See identical proteins and their annotated locations for XP_006513817.1

    UniProtKB/TrEMBL
    Q8C538
    Conserved Domains (1) summary
    pfam10267
    Location:34 → 432
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R310.2 GenPept UniProtKB/Swiss-Prot:Q8R310

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