sp8a sp8 transcription factor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sp8aprovided by ZNC
Official Full Name: sp8 transcription factor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9849
See related: Ensembl:ENSDARG00000011870 AllianceGenome:ZFIN:ZDB-GENE-030131-9849
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sp8; Sp8b; cb459; fa07g05; sb:cb459; zgc:85841; wu:fa07g05; wu:fa96f05
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including fin; median fin fold; nervous system; neural plate; and pectoral fin bud. Orthologous to human SP8 (Sp8 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (2315213..2318325, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (2483468..2486580, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sp8 and Sp9, via Fgf8, are involved in mediating the actions of Fgf10 and Wnt/beta-catenin signaling during vertebrate limb outgrowth.
Title: Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos.
activator of gata2 gene expression in the nervous system
Title: Pur alpha and Sp8 as opposing regulators of neural gata2 expression.

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General gene information

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Markers

fa07g05.s1 (e-PCR)
- UniSTS:202246

fa96f05 (e-PCR)
- UniSTS:188911

fb75a02.y1 (e-PCR)
- UniSTS:191225

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryo development	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor Sp8a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213241.2 → NP_998406.2 transcription factor Sp8a

See identical proteins and their annotated locations for NP_998406.2

Status: PROVISIONAL

Source sequence(s)

AY769697

UniProtKB/TrEMBL

A0A8N1TYG3, Q3L0W1

Related

ENSDARP00000008476.8, ENSDART00000012791.9

Conserved Domains (3) summary

sd00017
Location:285 → 304

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:340 → 362

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:326 → 349

zf-H2C2_2; Zinc-finger double domain