yy1a YY1 transcription factor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: yy1aprovided by ZNC
Official Full Name: YY1 transcription factor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1117
See related: Ensembl:ENSDARG00000042796 AllianceGenome:ZFIN:ZDB-GENE-030131-1117
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: yy1; fb59g10; wu:fa16g07; wu:fb59g10
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development; circulatory system development; and positive regulation of gene expression. Predicted to be part of PcG protein complex and transcription regulator complex. Is expressed in several structures, including eye; heart; myotome; notochord posterior region; and pronephros. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human YY1 (YY1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (30857011..30863252, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (30840057..30846256, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that YY1a regulates PS receptor expression that linked to function of PSR-phagocyte mediated apoptotic cell engulfment during development
Title: Knockdown of zebrafish YY1a can downregulate the phosphatidylserine (PS) receptor expression, leading to induce the abnormal brain and heart development.
YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression.
Title: Ubiquitous transcription factor YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression.
Study demonstrated that beta-arrestin1 is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 binds to and sequesters the PcG recruiter YY1, thus relieving PcG-mediated repression of cdx4-hox pathway.
Title: Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fb59g10.x1 (e-PCR)
- UniSTS:203355

fb5910 (e-PCR)
- UniSTS:187273

AI522672 (e-PCR)
- UniSTS:206318

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PcG protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcriptional repressor protein YY1a

Names: transcription factor Yy1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212617.2 → NP_997782.1 transcriptional repressor protein YY1a

See identical proteins and their annotated locations for NP_997782.1

Status: VALIDATED

Source sequence(s)

BX546455

UniProtKB/TrEMBL

F6NKM3, Q6IQQ3, Q7T1S3

Related

ENSDARP00000062810.4, ENSDART00000062811.6

Conserved Domains (4) summary

COG5048
Location:211 → 350

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:270 → 290

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:268 → 290

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:283 → 308

zf-H2C2_2; Zinc-finger double domain