inppl1a inositol polyphosphate phosphatase-like 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: inppl1aprovided by ZNC
Official Full Name: inositol polyphosphate phosphatase-like 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3904
See related: Ensembl:ENSDARG00000104222 AllianceGenome:ZFIN:ZDB-GENE-030131-3904
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ship2a; SHIP-2A; fc58a04; INPPL1-A; wu:fc58a04; zgc:198309
Summary: Predicted to enable actin binding activity and hydrolase activity. Acts upstream of or within BMP signaling pathway; negative regulation of fibroblast growth factor receptor signaling pathway; and negative regulation of neutrophil chemotaxis. Predicted to be located in nuclear speck. Is expressed in blastoderm and blastodisc. Human ortholog(s) of this gene implicated in hypertension; obesity; and type 2 diabetes mellitus. Orthologous to human INPPL1 (inositol polyphosphate phosphatase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (47454443..47498275, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (46990164..47016506, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SHIP phosphatases control neutrophil inflammation by limiting neutrophil motility in vivo.
Title: The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish.
Ship2a attenuates the FGF signaling pathway in vivo and functions in the establishment of normal tissue patterning in the early embryo.
Title: SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo.

Submit: New GeneRIF Correction

General gene information

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Markers

G41723 (e-PCR)
- UniSTS:42108

fc58a04 (e-PCR)
- UniSTS:189422

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables inositol-polyphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neutrophil chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A

Names: SH2 domain-containing inositol 5'-phosphatase 2A; SH2 domain-containing inositol phosphatase 2A; SH2-domain-containing inositol 5-phosphatase 2a; inositol polyphosphate phosphatase-like protein 1A

NP_001034893.1

EC 3.1.3.86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039804.2 → NP_001034893.1 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A

See identical proteins and their annotated locations for NP_001034893.1

Status: PROVISIONAL

Source sequence(s)

DQ272661

UniProtKB/Swiss-Prot

B7ZVH1, Q2I6J1

Related

ENSDARP00000129999.2, ENSDART00000164957.2

Conserved Domains (4) summary

cd09491
Location:1204 → 1263

SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins

cd09101
Location:408 → 711

INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins

smart00454
Location:1207 → 1263

SAM; Sterile alpha motif

cd10343
Location:15 → 113

SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)