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mnb minibrain [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32771, updated on 4-Jan-2025

Summary

Official Symbol
mnbprovided by FlyBase
Official Full Name
minibrainprovided by FlyBase
Primary source
FLYBASE:FBgn0259168
Locus tag
Dmel_CG42273
See related
AllianceGenome:FB:FBgn0259168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG42273; CG7826; CG7835; Dm1; DmDyrk1A; Dmel\CG42273; Dyrk1; DYRK1; Dyrk1a; Dyrk1A; DYRK1A; ME-IV; min; Minibrain; Mnb; MNB
Old locus tag
Dmel_CG7826; Dmel_CG7835
Summary
Enables protein kinase inhibitor activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of hippo signaling; olfactory learning; and positive regulation of developmental growth. Located in terminal bouton. Is expressed in several structures, including adult brain; adult mushroom body beta-lobe; embryonic/larval optic lobe; ganglia; and larval central brain. Used to study Down syndrome and syndromic intellectual disability. Human ortholog(s) of this gene implicated in Down syndrome; abdominal obesity-metabolic syndrome 3; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to several human genes including DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See mnb in Genome Data Viewer
Location:
16E2-16F1; 1-59 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17862697..17887222, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17756730..17781255, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43981 Neighboring gene Sulfiredoxin Neighboring gene Actin-related protein 8 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutathione synthetase 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

mobile_element

  • Loc: c17866676-17866569 mobile_element_type = transposon:INE-1{}4267

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
is_active_in nucleus  
located_in terminal bouton PubMed 

General protein information

Preferred Names
minibrain
Names
CG42273-PE
CG42273-PF
CG42273-PG
CG42273-PH
CG42273-PI
Dual-specificity tyrosine phosphorylation-regulated kinase 1A
minibrain kinase
mnb-PE
mnb-PF
mnb-PG
mnb-PH
mnb-PI
NP_001014750.1
NP_001285393.1
NP_728104.1
NP_728106.1
NP_728107.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17862697..17887222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167581.3 → NP_728104.1  minibrain, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728104.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49657, Q59E39, Q6AWJ3, Q9I7R8, Q9VX07
    Conserved Domains (2) summary
    smart00220
    Location:164 → 484
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:150 → 489
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  2. NM_170659.2 → NP_728107.2  minibrain, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728107.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VX06
    Conserved Domains (2) summary
    smart00220
    Location:303 → 623
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:289 → 628
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  3. NM_001014750.2 → NP_001014750.1  minibrain, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014750.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49657
    Conserved Domains (2) summary
    smart00220
    Location:164 → 484
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:150 → 489
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  4. NM_170658.3 → NP_728106.1  minibrain, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728106.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49657
    Conserved Domains (2) summary
    smart00220
    Location:164 → 484
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:150 → 489
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  5. NM_001298464.1 → NP_001285393.1  minibrain, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285393.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JFM3
    Conserved Domains (2) summary
    smart00220
    Location:303 → 623
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:289 → 628
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
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