U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tubgcp6 tubulin, gamma complex component 6 [ Mus musculus (house mouse) ]

Gene ID: 328580, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Tubgcp6provided by MGI
Official Full Name
tubulin, gamma complex component 6provided by MGI
Primary source
MGI:MGI:2146071
See related
Ensembl:ENSMUSG00000051786 AllianceGenome:MGI:2146071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GCP-6; mKIAA1669; D430023H11
Summary
Predicted to enable gamma-tubulin binding activity and microtubule binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to be part of gamma-tubulin large complex and gamma-tubulin small complex. Predicted to be active in centrosome and equatorial microtubule organizing center. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 1. Orthologous to human TUBGCP6 (tubulin gamma complex associated protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 11.9), genital fat pad adult (RPKM 11.8) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tubgcp6 in Genome Data Viewer
Location:
15 E3; 15 44.61 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (88983300..89007411, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89099097..89123208, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene pannexin 2 Neighboring gene RIKEN cDNA 1810021B22 gene Neighboring gene TraB domain containing Neighboring gene selenoprotein O Neighboring gene STARR-positive B cell enhancer ABC_E5508 Neighboring gene histone deacetylase 10 Neighboring gene STARR-positive B cell enhancer ABC_E8605 Neighboring gene mitogen-activated protein kinase 12

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation. Ansseau E, et al. PLoS One, 2016. PMID 26816005, Free PMC Article
  2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in equatorial microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin ring complex ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
gamma-tubulin complex component 6
Names
tubulin, gamma complex associated protein 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163319.1 → NP_001156791.1  gamma-tubulin complex component 6

    See identical proteins and their annotated locations for NP_001156791.1

    Status: VALIDATED

    Source sequence(s)
    AK052293, AK052441, BC057626, CF536834, CJ120677, CK637726
    Consensus CDS
    CCDS49697.1
    UniProtKB/Swiss-Prot
    G5E8P0, Q6PFC6, Q6ZPK3, Q8BWI2
    UniProtKB/TrEMBL
    E9Q6P4
    Related
    ENSMUSP00000104977.3, ENSMUST00000109353.9
    Conserved Domains (5) summary
    pfam09528
    Location:672 → 1249
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    pfam04130
    Location:355 → 611
    Spc97_Spc98; Spc97 / Spc98 family
    pfam08537
    Location:622 → 752
    NBP1; Fungal Nap binding protein NBP1
    pfam13863
    Location:689 → 785
    DUF4200; Domain of unknown function (DUF4200)
    pfam15346
    Location:631 → 759
    ARGLU; Arginine and glutamate-rich 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    88983300..89007411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159469.1 → XP_036015362.1  gamma-tubulin complex component 6 isoform X2

    Conserved Domains (3) summary
    pfam04130
    Location:946 → 1246
    Spc97_Spc98; Spc97 / Spc98 family
    pfam13868
    Location:137 → 292
    TPH; Trichohyalin-plectin-homology domain
    pfam17681
    Location:13 → 89
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  2. XM_006521093.2 → XP_006521156.1  gamma-tubulin complex component 6 isoform X1

    UniProtKB/TrEMBL
    E9Q6P4
    Conserved Domains (3) summary
    pfam04130
    Location:1466 → 1492
    Spc97_Spc98; Spc97 / Spc98 family
    pfam13868
    Location:645 → 815
    TPH; Trichohyalin-plectin-homology domain
    pfam17681
    Location:353 → 613
    GCP_N_terminal; Gamma tubulin complex component N-terminal

RNA

  1. XR_384017.3 RNA Sequence

  2. XR_384016.3 RNA Sequence

  3. XR_001781546.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5E8P0.1 GenPept UniProtKB/Swiss-Prot:G5E8P0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous