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Myorg myogenesis regulating glycosidase (putative) [ Mus musculus (house mouse) ]

Gene ID: 329828, updated on 12-May-2024

Summary

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Official Symbol
Myorgprovided by MGI
Official Full Name
myogenesis regulating glycosidase (putative)provided by MGI
Primary source
MGI:MGI:2140300
See related
Ensembl:ENSMUSG00000046312 AllianceGenome:MGI:2140300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm762; NET37; Kiaa1161
Summary
Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Acts upstream of or within positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; and skeletal muscle fiber development. Located in endoplasmic reticulum membrane and nuclear membrane. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human MYORG (myogenesis regulating glycosidase (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 7.2), liver adult (RPKM 7.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Myorg in Genome Data Viewer
Location:
4 A5; 4 21.69 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41495601..41503132, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41491847..41503135, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 24 Neighboring gene STARR-seq mESC enhancer starr_10033 Neighboring gene STARR-positive B cell enhancer ABC_E277 Neighboring gene nudix hydrolase 2 Neighboring gene STARR-seq mESC enhancer starr_10034 Neighboring gene sperm microtubule inner protein 6 Neighboring gene family with sequence similarity 219, member A, opposite strand Neighboring gene family with sequence similarity 219, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Biallelic Mutations in MYORG Cause Autosomal Recessive Primary Familial Brain Calcification. Yao XP, et al. Neuron, 2018 Jun 27. PMID 29910000
  2. NET37, a nuclear envelope transmembrane protein with glycosidase homology, is involved in myoblast differentiation. Datta K, et al. J Biol Chem, 2009 Oct 23. PMID 19706595, Free PMC Article
  3. An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells. Ogaki S, et al. BMC Dev Biol, 2011 Mar 1. PMID 21362171, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC175917

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle fiber development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle fiber development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myogenesis-regulating glycosidase
Names
full=Nuclear envelope transmembrane protein 37
nuclear envelope transmembrane protein 37
NP_001078984.1
XP_036020082.1
XP_036020083.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085515.2 → NP_001078984.1  myogenesis-regulating glycosidase

    See identical proteins and their annotated locations for NP_001078984.1

    Status: VALIDATED

    Source sequence(s)
    AL831723, BY246173, BY283520, CO044386
    Consensus CDS
    CCDS38716.1
    UniProtKB/Swiss-Prot
    A2ANN6, B2RU42, Q69ZQ1
    Related
    ENSMUSP00000059038.5, ENSMUST00000054920.5
    Conserved Domains (1) summary
    cd06592
    Location:313 → 684
    GH31_NET37; glucosidase NET37

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    41495601..41503132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164190.1 → XP_036020083.1  myogenesis-regulating glycosidase isoform X1

    UniProtKB/Swiss-Prot
    A2ANN6, B2RU42, Q69ZQ1
    Conserved Domains (1) summary
    cd06592
    Location:313 → 684
    GH31_NET37; glucosidase NET37

  2. XM_036164189.1 → XP_036020082.1  myogenesis-regulating glycosidase isoform X1

    UniProtKB/Swiss-Prot
    A2ANN6, B2RU42, Q69ZQ1
    Conserved Domains (1) summary
    cd06592
    Location:313 → 684
    GH31_NET37; glucosidase NET37
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZQ1.2 GenPept UniProtKB/Swiss-Prot:Q69ZQ1

Gene LinkOut

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