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Nep3 Neprilysin 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33005, updated on 4-Jan-2025

Summary

Official Symbol
Nep3provided by FlyBase
Official Full Name
Neprilysin 3provided by FlyBase
Primary source
FLYBASE:FBgn0031081
Locus tag
Dmel_CG9565
See related
AllianceGenome:FB:FBgn0031081
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CEC; CG9565; Dmel\CG9565; DmeNEP3; dNEP3; nep3; NEP3
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide hormone processing. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult brain; adult head; and spermatozoon. Human ortholog(s) of this gene implicated in Alzheimer's disease; congestive heart failure; coronary artery disease; essential hypertension; and hypertension. Orthologous to several human genes including ECE1 (endothelin converting enzyme 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Nep3 in Genome Data Viewer
Location:
19A3-19A3; 1-64 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19961297..19969323)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19855330..19863356)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene leaky Neighboring gene Dopamine 2-like receptor Neighboring gene transfer RNA:Proline-CGG 1-1

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloendopeptidase activity  
enables metalloendopeptidase activity  
enables metallopeptidase activity PubMed 
Process Evidence Code Pubs
involved_in peptide hormone processing  
involved_in protein processing  
involved_in proteolysis  
involved_in proteolysis PubMed 
Component Evidence Code Pubs
located_in membrane PubMed 
is_active_in plasma membrane  

General protein information

Preferred Names
neprilysin 3
Names
CG9565-PA
CG9565-PB
CG9565-PC
Nep3-PA
Nep3-PB
Nep3-PC
NP_001245775.1
NP_001245776.1
NP_523417.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19961297..19969323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258847.2 → NP_001245776.1  neprilysin 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245776.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SWS1, Q9W5Y0
    Conserved Domains (1) summary
    cd08662
    Location:123 → 784
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  2. NM_078693.3 → NP_523417.2  neprilysin 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523417.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SWS1, Q9W5Y0
    Related
    FBpp0070000
    Conserved Domains (1) summary
    cd08662
    Location:123 → 784
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  3. NM_001258846.1 → NP_001245775.1  neprilysin 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245775.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SWS1, Q9W5Y0
    Conserved Domains (1) summary
    cd08662
    Location:123 → 784
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
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