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HSPA1L heat shock protein family A (Hsp70) member 1 like [ Homo sapiens (human) ]

Gene ID: 3305, updated on 5-Jan-2025

Summary

Official Symbol
HSPA1Lprovided by HGNC
Official Full Name
heat shock protein family A (Hsp70) member 1 likeprovided by HGNC
Primary source
HGNC:HGNC:5234
See related
Ensembl:ENSG00000204390 MIM:140559; AllianceGenome:HGNC:5234
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP70T; hum70t; HSP70-1L; HSP70-HOM
Summary
This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 35.8) and ovary (RPKM 2.3) See more
Orthologs
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Genomic context

See HSPA1L in Genome Data Viewer
Location:
6p21.33
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (31809619..31815283, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (31662676..31668340, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31777396..31783060, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene valyl-tRNA synthetase 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:31759127-31759287 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:31759783-31760982 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:31763127-31763981 Neighboring gene LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:31782423-31783252 Neighboring gene origin of replication in promoter of HSPA1A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31783959-31784528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31784529-31785098 Neighboring gene heat shock protein family A (Hsp70) member 1A Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:31789548-31790747 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:31794443-31795254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31795278-31795907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31795908-31796536 Neighboring gene heat shock protein family A (Hsp70) member 1B

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis.
EBI GWAS Catalog
Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 1-like (HSPA1L), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 1-like (HSPA1L), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 1-like (HSPA1L), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 1-like (HSPA1L), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding  
enables ATP hydrolysis activity  
enables ATP-dependent protein folding chaperone  
enables heat shock protein binding  
enables heat shock protein binding PubMed 
enables protein binding PubMed 
enables protein folding chaperone  
enables ubiquitin protein ligase binding PubMed 
enables unfolded protein binding PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome PubMed 
located_in blood microparticle PubMed 
located_in cell body  
is_active_in cytoplasm  
is_active_in cytosol  
located_in cytosol PubMed 
located_in mitochondrial matrix  
located_in nucleoplasm  
is_active_in nucleus  
is_active_in plasma membrane  
part_of zona pellucida receptor complex  

General protein information

Preferred Names
heat shock 70 kDa protein 1-like
Names
epididymis secretory sperm binding protein
heat shock 10kDa protein 1-like
heat shock 70 kDa protein 1-Hom
heat shock 70 kDa protein 1L
heat shock 70kD protein-like 1
heat shock 70kDa protein 1-like
heat shock protein family A member 1L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011855.1 RefSeqGene

    Range
    4776..10440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005527.4NP_005518.3  heat shock 70 kDa protein 1-like

    See identical proteins and their annotated locations for NP_005518.3

    Status: REVIEWED

    Source sequence(s)
    AL671762, BC034483, BG717447, BX115051, CA443193, D85730, M59829
    Consensus CDS
    CCDS34413.1
    UniProtKB/Swiss-Prot
    A6NNB0, B0UXW8, O75634, P34931, Q2HXR3, Q8NE72, Q96QC9, Q9UQM1
    UniProtKB/TrEMBL
    A0A1U9X7W7, A0A1U9X7X9, B2RCQ9
    Related
    ENSP00000364805.4, ENST00000375654.5
    Conserved Domains (1) summary
    PTZ00009
    Location:4641
    PTZ00009; heat shock 70 kDa protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    31809619..31815283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    3142241..3147905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    3286871..3292534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    3057398..3063062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    3065448..3071111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    31662676..31668340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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