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HSPA8 heat shock protein family A (Hsp70) member 8 [ Homo sapiens (human) ]

Gene ID: 3312, updated on 5-Jan-2025

Summary

Official Symbol
HSPA8provided by HGNC
Official Full Name
heat shock protein family A (Hsp70) member 8provided by HGNC
Primary source
HGNC:HGNC:5241
See related
Ensembl:ENSG00000109971 MIM:600816; AllianceGenome:HGNC:5241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; LAP-1; NIP71; HEL-33; HSPA10; HEL-S-72p
Summary
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in brain (RPKM 443.0), kidney (RPKM 352.5) and 25 other tissues See more
Orthologs
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Genomic context

See HSPA8 in Genome Data Viewer
Location:
11q24.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (123057489..123062462, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (123086071..123093285, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (122928197..122932844, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 pseudogene 43 Neighboring gene ribosomal protein L31 pseudogene 47 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5676 Neighboring gene uncharacterized LOC124902775 Neighboring gene small nucleolar RNA, C/D box 14E Neighboring gene small nucleolar RNA, C/D box 14D Neighboring gene small nucleolar RNA, C/D box 14C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4012 Neighboring gene Sharpr-MPRA regulatory region 9139 Neighboring gene CXADR like membrane protein Neighboring gene ReSE screen-validated silencer GRCh37_chr11:123005125-123005345 Neighboring gene FUN14 domain-containing protein 1-like

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 8 (HSPA8, HSC70), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 8 (HSPA8, HSC70), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 8 (HSPA8, HSC70), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
nef Heat shock proteins Hsp40 and Hsp70 interact with HIV-1 Nef and form a complex in cells PubMed
nef HIV-1 Nef increases the production of exosomes and co-localizes with exosomal proteins CD63, AIP/Alix, AChE, Hsc70, LAMP2, and annexin A2 in HeLa cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heat shock 70kDa protein 8 (HSPA8, HSC70), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
gag Hsc70 is specifically incorporated into HIV-1 virions, similar to Hsp70 which is incorporated into virions through an interaction with HIV-1 Gag PubMed
Tat tat Heat shock 70kDa protein 8 (HSPA8) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
Vif vif HIV-1 Vif interacts with HSPA8; predicted interaction to be relevant to gene regulation PubMed
Vpr vpr HIV-1 Vpr is required for the inhibitory effect of Hsp70 on viral gene expression and replication PubMed
vpr HIV-1 Vpr competes with Hsp70 for binding to karyopherin alpha PubMed
matrix gag Hsp70 facilitates nuclear import of HIV-1 preintegration complexes by stimulating the binding of HIV-1 Matrix to karyopherin alpha PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC29929, MGC131511

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding PubMed 
enables ATP hydrolysis activity  
enables ATP hydrolysis activity PubMed 
enables ATP hydrolysis activity  
enables ATP-dependent protein disaggregase activity PubMed 
enables ATP-dependent protein folding chaperone  
enables C3HC4-type RING finger domain binding PubMed 
enables G protein-coupled receptor binding PubMed 
enables MHC class II protein complex binding PubMed 
enables RNA binding PubMed 
enables cadherin binding PubMed 
enables enzyme binding PubMed 
enables heat shock protein binding  
enables heat shock protein binding PubMed 
enables protein binding PubMed 
enables protein carrier chaperone PubMed 
enables protein folding chaperone  
enables protein-folding chaperone binding PubMed 
enables protein-macromolecule adaptor activity PubMed 
enables protein-macromolecule adaptor activity PubMed 
enables receptor ligand activity PubMed 
enables ubiquitin protein ligase binding PubMed 
enables unfolded protein binding PubMed 
Items 1 - 25 of 27
Process Evidence Code Pubs
involved_in ATP metabolic process PubMed 
involved_in cellular response to starvation PubMed 
involved_in cellular response to steroid hormone stimulus  
involved_in chaperone cofactor-dependent protein refolding  
involved_in chaperone-mediated autophagy  
involved_in chaperone-mediated autophagy PubMed 
involved_in chaperone-mediated autophagy translocation complex disassembly  
involved_in clathrin coat disassembly  
involved_in clathrin coat disassembly PubMed 
involved_in mRNA splicing, via spliceosome PubMed 
involved_in membrane organization  
involved_in negative regulation of DNA-templated transcription PubMed 
involved_in negative regulation of NLRP3 inflammasome complex assembly PubMed 
involved_in negative regulation of supramolecular fiber organization PubMed 
involved_in positive regulation of cell migration PubMed 
involved_in protein folding PubMed 
involved_in protein refolding  
involved_in protein refolding PubMed 
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy PubMed 
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy PubMed 
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy PubMed 
involved_in regulation of protein complex stability  
involved_in regulation of protein import PubMed 
involved_in regulation of protein stability PubMed 
involved_in regulation of protein-containing complex assembly PubMed 
involved_in response to unfolded protein PubMed 
involved_in signal transduction  
Items 1 - 25 of 27
Items 1 - 20 of 31
Component Evidence Code Pubs
part_of Prp19 complex PubMed 
part_of Prp19 complex PubMed 
located_in blood microparticle PubMed 
located_in clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane  
is_active_in cytoplasm  
is_active_in cytosol  
located_in cytosol PubMed 
located_in cytosol  
located_in extracellular exosome PubMed 
located_in extracellular exosome PubMed 
located_in extracellular region  
located_in extracellular space PubMed 
is_active_in extracellular space PubMed 
located_in ficolin-1-rich granule lumen  
located_in focal adhesion PubMed 
located_in lumenal side of lysosomal membrane PubMed 
located_in lysosomal lumen PubMed 
is_active_in lysosomal membrane PubMed 
located_in lysosomal membrane  
located_in melanosome  
located_in membrane PubMed 
located_in nucleolus  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 
is_active_in plasma membrane  
located_in plasma membrane  
part_of protein folding chaperone complex PubMed 
part_of ribonucleoprotein complex PubMed 
located_in secretory granule lumen  
part_of spliceosomal complex PubMed 
Items 1 - 20 of 31

General protein information

Preferred Names
heat shock cognate 71 kDa protein
Names
LPS-associated protein 1
N-myristoyltransferase inhibitor protein 71
constitutive heat shock protein 70
epididymis luminal protein 33
epididymis secretory sperm binding protein Li 72p
heat shock 70kDa protein 8
heat shock 70kd protein 10
heat shock cognate protein 54
heat shock protein family A member 8
lipopolysaccharide-associated protein 1
NP_006588.1
NP_694881.1
XP_011541100.1
XP_054224589.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029473.1 RefSeqGene

    Range
    5001..9648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006597.6NP_006588.1  heat shock cognate 71 kDa protein isoform 1

    See identical proteins and their annotated locations for NP_006588.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AK222628, AP000926, BC019816, DC395565
    Consensus CDS
    CCDS8440.1
    UniProtKB/Swiss-Prot
    P11142, Q9H3R6
    UniProtKB/TrEMBL
    Q53GZ6, V9HW22
    Related
    ENSP00000432083.1, ENST00000534624.6
    Conserved Domains (1) summary
    PTZ00009
    Location:1613
    PTZ00009; heat shock 70 kDa protein; Provisional
  2. NM_153201.4NP_694881.1  heat shock cognate 71 kDa protein isoform 2

    See identical proteins and their annotated locations for NP_694881.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites, and is missing an exon in the 3' coding region compared to variant 1. However, it maintains the reading frame, and encodes a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AB034951, AK222628, AP000926, DC395565
    Consensus CDS
    CCDS44754.1
    UniProtKB/TrEMBL
    Q53HF2
    Related
    ENSP00000404372.2, ENST00000453788.6
    Conserved Domains (1) summary
    PTZ00009
    Location:1462
    PTZ00009; heat shock 70 kDa protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    123057489..123062462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542798.2XP_011541100.1  heat shock cognate 71 kDa protein isoform X1

    See identical proteins and their annotated locations for XP_011541100.1

    UniProtKB/Swiss-Prot
    P11142, Q9H3R6
    UniProtKB/TrEMBL
    Q53GZ6, V9HW22
    Conserved Domains (1) summary
    PTZ00009
    Location:1613
    PTZ00009; heat shock 70 kDa protein; Provisional

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    123086071..123093285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368614.1XP_054224589.1  heat shock cognate 71 kDa protein isoform X1

    UniProtKB/Swiss-Prot
    P11142, Q9H3R6
    UniProtKB/TrEMBL
    Q53GZ6, V9HW22
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