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Serpina7 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 [ Mus musculus (house mouse) ]

Gene ID: 331535, updated on 4-Jan-2025

Summary

Official Symbol
Serpina7provided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7provided by MGI
Primary source
MGI:MGI:3041197
See related
Ensembl:ENSMUSG00000031271 AllianceGenome:MGI:3041197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tbg; C730040N12Rik
Summary
Predicted to enable hormone binding activity. Predicted to be involved in several processes, including response to vitamin A; response to xenobiotic stimulus; and thyroid hormone transport. Predicted to be active in extracellular space. Orthologous to human SERPINA7 (serpin family A member 7). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in liver E18 (RPKM 13.9), liver E14.5 (RPKM 1.1) and 2 other tissues See more
Orthologs
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Genomic context

See Serpina7 in Genome Data Viewer
Location:
X F1; X 61.23 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (137979998..137985985, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (139079249..139085236, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor accessory protein-like 2 Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47989 Neighboring gene RIKEN cDNA 4930513O06 gene Neighboring gene Nik related kinase Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 

Interactions

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in post-embryonic development  
involved_in response to vitamin A  
involved_in response to xenobiotic stimulus  
involved_in thyroid hormone transport  
Component Evidence Code Pubs
is_active_in extracellular space  
located_in extracellular space  
located_in extracellular space  

General protein information

Preferred Names
thyroxine-binding globulin
Names
T4-binding globulin
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antipeptidase, antitrypsin), member 7
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
serpin A7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382371.1NP_001369300.1  thyroxine-binding globulin isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL732419
    UniProtKB/Swiss-Prot
    A2RSG7, P61939
    Conserved Domains (1) summary
    cd19555
    Location:40418
    serpinA7_TBG; serpin family A member 7, thyroxine-binding globulin
  2. NM_001382372.1NP_001369301.1  thyroxine-binding globulin isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL732419
    UniProtKB/Swiss-Prot
    A2RSG7, P61939
    Conserved Domains (1) summary
    cd19555
    Location:40418
    serpinA7_TBG; serpin family A member 7, thyroxine-binding globulin
  3. NM_177920.5NP_808588.3  thyroxine-binding globulin isoform 1 precursor

    See identical proteins and their annotated locations for NP_808588.3

    Status: VALIDATED

    Source sequence(s)
    AK050361, AK149459, BP767390, BY099279
    Consensus CDS
    CCDS53200.1
    UniProtKB/TrEMBL
    Q3UEL9
    Related
    ENSMUSP00000033626.9, ENSMUST00000033626.15
    Conserved Domains (1) summary
    cd02056
    Location:57419
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    137979998..137985985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528579.3XP_006528642.1  thyroxine-binding globulin isoform X1

    UniProtKB/TrEMBL
    Q8BII9
    Related
    ENSMUSP00000056166.3, ENSMUST00000060824.4
    Conserved Domains (1) summary
    cl38926
    Location:3249
    serpin; SERine Proteinase INhibitors (serpin) family
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