U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

N4bp2 NEDD4 binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 333789, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
N4bp2provided by MGI
Official Full Name
NEDD4 binding protein 2provided by MGI
Primary source
MGI:MGI:2684414
See related
Ensembl:ENSMUSG00000037795 AllianceGenome:MGI:2684414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B3bp; Gm868; Gm1791; E430014I16
Summary
Predicted to enable ATP binding activity; endonuclease activity; and polydeoxyribonucleotide 5'-hydroxyl-kinase activity. Predicted to act upstream of or within phosphorylation. Located in cytosol. Is expressed in ovary and primary sex cord. Orthologous to human N4BP2 (NEDD4 binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 6.8), limb E14.5 (RPKM 6.3) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5 C3.1; 5 33.8 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65909462..65987450)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65760510..65830107)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40309 Neighboring gene ubiquitin-conjugating enzyme E2K Neighboring gene PDS5 cohesin associated factor A Neighboring gene STARR-seq mESC enhancer starr_13267 Neighboring gene predicted gene, 24399 Neighboring gene STARR-positive B cell enhancer ABC_E3578 Neighboring gene STARR-seq mESC enhancer starr_13273 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66156164-66156347 Neighboring gene predicted gene 5296 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66186562-66186763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66242163-66242364 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66249264-66249516 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66254646-66254891 Neighboring gene predicted gene 3521 Neighboring gene ras homolog family member H

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. Murillas R, et al. J Biol Chem, 2002 Jan 25. PMID 11717310
  2. Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad. McClive PJ, et al. Genesis, 2003 Oct. PMID 14595844
  3. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Villegas F, et al. Cell Stem Cell, 2019 Feb 7. PMID 30595499
  4. Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. Watanabe N, et al. J Biol Chem, 2003 Jul 11. PMID 12730195
  5. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
NEDD4-binding protein 2
Names
Bcl3 binding protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024917.1 → NP_001020088.1  NEDD4-binding protein 2

    See identical proteins and their annotated locations for NP_001020088.1

    Status: VALIDATED

    Source sequence(s)
    AK173167, BC054549, CK637074, CX769144
    Consensus CDS
    CCDS19310.1
    UniProtKB/TrEMBL
    A0A0J9YUP5, F8VQG7
    Related
    ENSMUSP00000143807.2, ENSMUST00000201489.4
    Conserved Domains (4) summary
    smart00463
    Location:1596 → 1678
    SMR; Small MutS-related domain
    COG5099
    Location:92 → 253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:1529 → 1590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372 → 498
    AAA_33; AAA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    65909462..65987450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254611.2 → XP_030110471.1  NEDD4-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0J9YUP5
    Conserved Domains (5) summary
    smart00463
    Location:1676 → 1758
    SMR; Small MutS-related domain
    COG5099
    Location:172 → 333
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:47 → 87
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:1609 → 1670
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:452 → 578
    AAA_33; AAA domain

  2. XM_036165236.1 → XP_036021129.1  NEDD4-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0J9YUP5, F8VQG7
    Conserved Domains (4) summary
    smart00463
    Location:1596 → 1678
    SMR; Small MutS-related domain
    COG5099
    Location:92 → 253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:1529 → 1590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372 → 498
    AAA_33; AAA domain

  3. XM_030254610.2 → XP_030110470.1  NEDD4-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0J9YUP5
    Conserved Domains (5) summary
    smart00463
    Location:1676 → 1758
    SMR; Small MutS-related domain
    COG5099
    Location:172 → 333
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:47 → 87
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:1609 → 1670
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:452 → 578
    AAA_33; AAA domain

  4. XM_006504004.5 → XP_006504067.1  NEDD4-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006504067.1

    UniProtKB/TrEMBL
    A0A0J9YUP5
    Conserved Domains (5) summary
    smart00463
    Location:1703 → 1785
    SMR; Small MutS-related domain
    COG5099
    Location:199 → 360
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:74 → 114
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:1636 → 1697
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:479 → 605
    AAA_33; AAA domain

  5. XM_030254615.2 → XP_030110475.1  NEDD4-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0J9YUP5, F8VQG7
    Conserved Domains (4) summary
    smart00463
    Location:1596 → 1678
    SMR; Small MutS-related domain
    COG5099
    Location:92 → 253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:1529 → 1590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372 → 498
    AAA_33; AAA domain

  6. XM_006504003.3 → XP_006504066.1  NEDD4-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006504066.1

    UniProtKB/TrEMBL
    A0A0J9YUP5
    Conserved Domains (5) summary
    smart00463
    Location:1703 → 1785
    SMR; Small MutS-related domain
    COG5099
    Location:199 → 360
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:74 → 114
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:1636 → 1697
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:479 → 605
    AAA_33; AAA domain

  7. XM_006504007.4 → XP_006504070.1  NEDD4-binding protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006504070.1

    UniProtKB/TrEMBL
    A0A0J9YUP5, F8VQG7
    Related
    ENSMUSP00000084519.4, ENSMUST00000087264.4
    Conserved Domains (4) summary
    smart00463
    Location:1596 → 1678
    SMR; Small MutS-related domain
    COG5099
    Location:92 → 253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:1529 → 1590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372 → 498
    AAA_33; AAA domain

  8. XM_006504006.5 → XP_006504069.1  NEDD4-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0J9YUP5
    Conserved Domains (5) summary
    smart00463
    Location:1676 → 1758
    SMR; Small MutS-related domain
    COG5099
    Location:172 → 333
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:47 → 87
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:1609 → 1670
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:452 → 578
    AAA_33; AAA domain

  9. XM_030254614.1 → XP_030110474.1  NEDD4-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0J9YUP5, F8VQG7
    Conserved Domains (4) summary
    smart00463
    Location:1596 → 1678
    SMR; Small MutS-related domain
    COG5099
    Location:92 → 253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:1529 → 1590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372 → 498
    AAA_33; AAA domain

  10. XM_030254609.2 → XP_030110469.1  NEDD4-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0J9YUP5
    Conserved Domains (5) summary
    smart00463
    Location:1676 → 1758
    SMR; Small MutS-related domain
    COG5099
    Location:172 → 333
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:47 → 87
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:1609 → 1670
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:452 → 578
    AAA_33; AAA domain

  11. XM_030254612.1 → XP_030110472.1  NEDD4-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0J9YUP5, F8VQG7
    Conserved Domains (4) summary
    smart00463
    Location:1596 → 1678
    SMR; Small MutS-related domain
    COG5099
    Location:92 → 253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:1529 → 1590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372 → 498
    AAA_33; AAA domain

  12. XM_030254613.1 → XP_030110473.1  NEDD4-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0J9YUP5, F8VQG7
    Conserved Domains (4) summary
    smart00463
    Location:1596 → 1678
    SMR; Small MutS-related domain
    COG5099
    Location:92 → 253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:1529 → 1590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372 → 498
    AAA_33; AAA domain

  13. XM_011240752.3 → XP_011239054.1  NEDD4-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011239054.1

    UniProtKB/TrEMBL
    A0A0J9YUP5
    Conserved Domains (5) summary
    smart00463
    Location:1703 → 1785
    SMR; Small MutS-related domain
    COG5099
    Location:199 → 360
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:74 → 114
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:1636 → 1697
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:479 → 605
    AAA_33; AAA domain

  14. XM_006504005.4 → XP_006504068.1  NEDD4-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006504068.1

    UniProtKB/TrEMBL
    A0A0J9YUP5
    Conserved Domains (5) summary
    smart00463
    Location:1703 → 1785
    SMR; Small MutS-related domain
    COG5099
    Location:199 → 360
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:74 → 114
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:1636 → 1697
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:479 → 605
    AAA_33; AAA domain

  15. XM_017320937.2 → XP_017176426.1  NEDD4-binding protein 2 isoform X4

    Conserved Domains (2) summary
    smart00463
    Location:1105 → 1187
    SMR; Small MutS-related domain
    pfam08590
    Location:1038 → 1099
    DUF1771; Domain of unknown function (DUF1771)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous