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By fusing the MCF-7 binding peptide (MBP) to the C-terminus of IFNalpha, we constructed an engineered IFNalpha-MBP fusion molecule (IMBP), and applied this novel fusion protein to the treatment of breast cancer. We found that IMBP exhibited significantly higher activity than wild-type IFNalpha in inhibiting cell growth and inducing cell apoptosis
Title: A novel engineered interferon-α hybrid molecule increases anticancer efficacy of doxorubicin in breast cancer chemotherapy.
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These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter.
Title: Type I IFNs downregulate myeloid cell IFN-γ receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription.
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monocytes manage the impact of TNF-alpha and type I/II interferons in rheumatoid arthritis and systemic lupus erythematosus
Title: The multifaceted balance of TNF-α and type I/II interferon responses in SLE and RA: how monocytes manage the impact of cytokines.
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NS1 binds to MAVS and this binding inhibits the MAVS-RIG-I interaction required for IFN production
Title: Respiratory syncytial virus NS1 protein colocalizes with mitochondrial antiviral signaling protein MAVS following infection.
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IFN-alpha increased the percentage of lymphocytes staining positive for intracellular phosphorylated p38. IFNA-induced increases in p-p38 were significantly greater in patients that developed clinically significant depressive symptoms.
Title: Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression and fatigue.
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Regulation of IFN response gene activity upon TNF blockade in rheumatoid arthritis is not as consistent as previously described, but varies between patients
Title: Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment.
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Psoriasis patients produce markedly increased levels of auto Abs to TNF-alpha and IFN-alpha which are two of the key cytokines in this disorder
Title: Psoriasis patients generate increased serum levels of autoantibodies to tumor necrosis factor-alpha and interferon-alpha.
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transient binding of both IRF-3 and IRF-7, accompanied by CBP/p300 recruitment to the endogenous IFN-A gene promoters, is associated with transcriptional activation
Title: Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7.
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A novel model in which IL-12 and IFN-alpha act in a nonredundant manner to regulate the colinear generation of both effector and memory cells.
Title: Reciprocal responsiveness to interleukin-12 and interferon-alpha specifies human CD8+ effector versus central memory T-cell fates.
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Human monocytes produce abundant IFN-alpha following Toll-like receptor-4 engagement, whether the cells have been pretreated either with IFN-beta or with a supernatant from dendritic cells activated by RNA-containing immune complexes from lupus patients.
Title: TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming.