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IGHE immunoglobulin heavy constant epsilon [ Homo sapiens (human) ]

Gene ID: 3497, updated on 4-Jan-2025

Summary

Official Symbol
IGHEprovided by HGNC
Official Full Name
immunoglobulin heavy constant epsilonprovided by HGNC
Primary source
HGNC:HGNC:5522
See related
Ensembl:ENSG00000211891 IMGT/GENE-DB:IGHE; MIM:147180; AllianceGenome:HGNC:5522
Gene type
other
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IgE
Summary
Enables immunoglobulin receptor binding activity. Involved in several processes, including B cell mediated immunity; Fc receptor-mediated immune complex endocytosis; and leukocyte degranulation. Located in extracellular space and plasma membrane. Part of IgE B cell receptor complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See IGHE in Genome Data Viewer
Location:
14q32.33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105600066..105601727, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (99852516..99854177, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106066403..106068064, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370698 Neighboring gene ETS transcription factor ELK2B, pseudogene Neighboring gene microRNA 8071-1 Neighboring gene immunoglobulin heavy constant alpha 2 (A2m marker) Neighboring gene immunoglobulin heavy locus Neighboring gene immunoglobulin heavy constant gamma 4 (G4m marker)

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Other Names

  • constant region of heavy chain of IgE
  • immunoglobulin epsilon

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding  
enables antigen binding PubMed 
enables immunoglobulin receptor binding  
enables immunoglobulin receptor binding PubMed 
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in B cell antigen processing and presentation PubMed 
involved_in B cell proliferation PubMed 
involved_in B cell receptor signaling pathway PubMed 
involved_in B cell receptor signaling pathway PubMed 
involved_in Fc receptor-mediated immune complex endocytosis PubMed 
involved_in adaptive immune memory response PubMed 
involved_in adaptive immune response PubMed 
involved_in antibacterial humoral response  
involved_in antibody-dependent cellular cytotoxicity PubMed 
involved_in complement activation, classical pathway  
involved_in eosinophil degranulation PubMed 
involved_in immune response PubMed 
involved_in inflammatory response  
involved_in macrophage activation PubMed 
involved_in macrophage differentiation PubMed 
involved_in mast cell degranulation PubMed 
involved_in primary adaptive immune response PubMed 
involved_in type 2 immune response PubMed 
involved_in type I hypersensitivity PubMed 
Component Evidence Code Pubs
part_of IgE B cell receptor complex PubMed 
part_of IgE immunoglobulin complex PubMed 
located_in extracellular region  
located_in extracellular space PubMed 
located_in extracellular space PubMed 
part_of immunoglobulin complex, circulating  
located_in plasma membrane PubMed 
located_in plasma membrane PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001019.6 

    Range
    1278618..1280403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    105600066..105601727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187600.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    67840..69501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    99852516..99854177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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