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IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker) [ Homo sapiens (human) ]

Gene ID: 3502, updated on 4-Jan-2025

Summary

Official Symbol
IGHG3provided by HGNC
Official Full Name
immunoglobulin heavy constant gamma 3 (G3m marker)provided by HGNC
Primary source
HGNC:HGNC:5527
See related
Ensembl:ENSG00000211897 IMGT/GENE-DB:IGHG3; MIM:147120; AllianceGenome:HGNC:5527
Gene type
other
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IgG3
Summary
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in antibacterial humoral response and complement activation, classical pathway. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

See IGHG3 in Genome Data Viewer
Location:
14q32.33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105765914..105771405, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (100037379..100042856, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106232251..106237742, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy locus Neighboring gene uncharacterized LOC105378184 Neighboring gene MPRA-validated peak2261 silencer Neighboring gene ATP6V1G1P1-IGHD intergenic CAGE-defined B cell enhancer Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 1 Neighboring gene immunoglobulin heavy constant epsilon P1 (pseudogene) Neighboring gene immunoglobulin heavy constant gamma 1 (G1m marker) Neighboring gene immunoglobulin heavy constant delta

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.
EBI GWAS Catalog

Interactions

General gene information

Other Names

  • C gamma 3
  • constant region of heavy chain of IgG3
  • immunoglobulin gamma 3 (Gm marker)
  • immunoglobulin heavy constant gamma 3 (Gm marker)
  • secrete-type Ig gamma heavy-chain

Clone Names

  • FLJ39988, FLJ40036, FLJ40253, FLJ40587, FLJ40789, FLJ40834, MGC45809, DKFZp686H11213

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding  
enables immunoglobulin receptor binding  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001019.6 

    Range
    1108940..1114431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    105765914..105771405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187600.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    233683..239174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    100037379..100042856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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