selenom selenoprotein M [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: selenomprovided by ZNC
Official Full Name: selenoprotein Mprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030410-4
See related: Ensembl:ENSDARG00000051957 AllianceGenome:ZFIN:ZDB-GENE-030410-4
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: selm; sepm; cb693; fc13f12; wu:fc13f12; zgc:103431
Summary: The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known, but it may have a role in maintaining redox homeostasis. It is localized in the perinuclear region, and is highly expressed in the brain in mammals. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (69278089..69287567)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (68505740..68515198)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: selenoprotein M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178286.4 → NP_840071.2 selenoprotein M precursor

Status: REVIEWED

Source sequence(s)

EH538512, EH541157, EH559733

UniProtKB/Swiss-Prot

Q5XJC8, Q802G7

UniProtKB/TrEMBL

A0A8M1PC15

Related

ENSDARP00000119889.1, ENSDART00000136656.2

Conserved Domains (1) summary

pfam08806
Location:30 → 104

Sep15_SelM; Sep15/SelM redox domain