Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp11b3provided by RGD
Official Full Name: cytochrome P450, family 11, subfamily b, polypeptide 3provided by RGD
Primary source: RGD:727886
See related: AllianceGenome:RGD:727886
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CYPXIB3
Summary: Enables corticosterone 18-monooxygenase activity and steroid 11-beta-monooxygenase activity. Involved in adrenal gland development; response to peptide hormone; and steroid metabolic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); dilated cardiomyopathy 1H; hypertension (multiple); and primary hyperaldosteronism. Orthologous to human CYP11B2 (cytochrome P450 family 11 subfamily B member 2). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: suggests misassembly
Expression: Restricted expression toward (RPKM 11953.3) See more
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Genomic context

Location:: 7q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (108689319..108694808, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (106808559..106814048, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (116155928..116161781, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables corticosterone 18-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticosterone 18-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables steroid 11-beta-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid 11-beta-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables steroid 11-beta-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables steroid 11-beta-monooxygenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in C21-steroid hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in adrenal gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in aldosterone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within aldosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in aldosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to peptide hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to potassium ion	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cortisol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within drinking behavior	ISO Inferred from Sequence Orthology more info
involved_in glucocorticoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood volume by renal aldosterone	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood volume by renal aldosterone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure by circulatory renin-angiotensin	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450, family 11, subfamily b, polypeptide 3

Names: cytochrome P450, subfamily 11B, polypeptide 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.