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ACC Acetyl-CoA carboxylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35761, updated on 11-Apr-2024

Summary

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Official Symbol
ACCprovided by FlyBase
Official Full Name
Acetyl-CoA carboxylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0033246
Locus tag
Dmel_CG11198
See related
AllianceGenome:FB:FBgn0033246
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
A1Z784_DROME; acc; Acc; ACoT; CG11198; CG8723; dACC; DmACC; Dmel\CG11198; FBgn0043811
Summary
Predicted to enable ATP binding activity; acetyl-CoA carboxylase activity; and metal ion binding activity. Involved in several processes, including cellular response to sucrose stimulus; glycogen metabolic process; and triglyceride biosynthetic process. Located in cytoplasm. Is expressed in several structures, including adult heart; embryonic/larval fat body; embryonic/larval gut; embryonic/larval oenocyte; and spermatozoon. Orthologous to several human genes including ACACB (acetyl-CoA carboxylase beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
44A1-44A2; 2-58 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7974115..7991862, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3861620..3879367, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene spenito Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 4 Neighboring gene Nucleoporin at 44A Neighboring gene long non-coding RNA:CR44272 Neighboring gene Dicarboxylate carrier 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inhibition of acetyl-CoA carboxylase impaired tubulin palmitoylation and induced spindle abnormalities. Fang CT, et al. Cell Death Discov, 2023 Jan 9. PMID 36617578, Free PMC Article
  2. Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model. Saka SO, et al. Molecules, 2023 Jan 5. PMID 36677591, Free PMC Article
  3. Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP. Ziegler AB, et al. Cell Rep, 2017 Dec 19. PMID 29262315
  4. Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila. Katewa SD, et al. Cell Metab, 2016 Jan 12. PMID 26626459, Free PMC Article
  5. Drosophila STING protein has a role in lipid metabolism. Akhmetova K, et al. Elife, 2021 Sep 1. PMID 34467853, Free PMC Article

See all (147) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetyl-CoA carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetyl-CoA carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables biotin carboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to sucrose stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to sucrose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Acetyl-CoA carboxylase
Names
ACC-PA
ACC-PB
ACC-PC
ACC-PE
ACC-PF
ACC-PG
CG11198-PA
CG11198-PB
CG11198-PC
CG11198-PE
CG11198-PF
CG11198-PG
aceto-acetyl-CoA-thiolase
acetyl CoA carboxylase
acetyl coenzyme A carboxylase
acetyl-CoA carboxylase
acetyl-CoA-carboxylase
acetyl-coenzyme A carboxylase
acyl-coA carboxylase
NP_001097226.1
NP_001097227.2
NP_001286177.1
NP_001286178.1
NP_610342.1
NP_724636.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7974115..7991862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299249.1 → NP_001286178.1  Acetyl-CoA carboxylase, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286178.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JV23
    Conserved Domains (7) summary
    cd06850
    Location:732 → 793
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    COG0439
    Location:101 → 598
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:101 → 220
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam01039
    Location:1641 → 2185
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:485 → 592
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:797 → 1541
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:225 → 448
    ATP-grasp_4; ATP-grasp domain

  2. NM_001299248.1 → NP_001286177.1  Acetyl-CoA carboxylase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286177.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JV23
    Conserved Domains (7) summary
    cd06850
    Location:732 → 793
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    COG0439
    Location:101 → 598
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:101 → 220
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam01039
    Location:1641 → 2185
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:485 → 592
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:797 → 1541
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:225 → 448
    ATP-grasp_4; ATP-grasp domain

  3. NM_165581.3 → NP_724636.1  Acetyl-CoA carboxylase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724636.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JV23
    Related
    FBpp0087948
    Conserved Domains (7) summary
    cd06850
    Location:732 → 793
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    COG0439
    Location:101 → 598
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:101 → 220
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam01039
    Location:1641 → 2185
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:485 → 592
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:797 → 1541
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:225 → 448
    ATP-grasp_4; ATP-grasp domain

  4. NM_136498.3 → NP_610342.1  Acetyl-CoA carboxylase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610342.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z784
    Related
    FBpp0087947
    Conserved Domains (7) summary
    cd06850
    Location:891 → 952
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    COG0439
    Location:260 → 757
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:260 → 379
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam01039
    Location:1800 → 2344
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:644 → 751
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:956 → 1700
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:384 → 607
    ATP-grasp_4; ATP-grasp domain

  5. NM_001103756.3 → NP_001097226.1  Acetyl-CoA carboxylase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097226.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JV23
    Conserved Domains (7) summary
    cd06850
    Location:732 → 793
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    COG0439
    Location:101 → 598
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:101 → 220
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam01039
    Location:1641 → 2185
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:485 → 592
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:797 → 1541
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:225 → 448
    ATP-grasp_4; ATP-grasp domain

  6. NM_001103757.3 → NP_001097227.2  Acetyl-CoA carboxylase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097227.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY67
    Conserved Domains (7) summary
    cd06850
    Location:757 → 818
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    COG0439
    Location:126 → 623
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00289
    Location:126 → 245
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam01039
    Location:1666 → 2210
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:510 → 617
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:822 → 1566
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:250 → 473
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z784 A1Z784
A8DY67 A8DY67
Q7JV23 Q7JV23

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