U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

beta3GalTII beta-1,3-Galactosyltransferase II [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35848, updated on 10-May-2024

Summary

Go to the top of the page Help
Official Symbol
beta3GalTIIprovided by FlyBase
Official Full Name
beta-1,3-Galactosyltransferase IIprovided by FlyBase
Primary source
FLYBASE:FBgn0033315
Locus tag
Dmel_CG8734
See related
AllianceGenome:FB:FBgn0033315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8734; dbeta3GalTII; dGAGbeta3GalTII; Dmel\CG8734; GalTII
Summary
Enables galactosylxylosylprotein 3-beta-galactosyltransferase activity. Involved in glycosaminoglycan biosynthetic process and heparan sulfate proteoglycan biosynthetic process. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome spondylodysplastic type 2 and spondyloepimetaphyseal dysplasia with joint laxity type 1. Orthologous to human B3GALT6 (beta-1,3-galactosyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See beta3GalTII in Genome Data Viewer
Location:
44D5-44D5; 2-59 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8626181..8627611, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4513686..4515116, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Calcium-independent receptor for alpha-latrotoxin Neighboring gene Vacuolar protein sorting 25 Neighboring gene Gle1 RNA export mediator Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Drosophila gene brainiac encodes a glycosyltransferase putatively involved in glycosphingolipid synthesis. Schwientek T, et al. J Biol Chem, 2002 Sep 6. PMID 12130651
  2. Functional analysis of proteoglycan galactosyltransferase II RNA interference mutant flies. Ueyama M, et al. J Biol Chem, 2008 Mar 7. PMID 18165227
  3. A translational block to HSPG synthesis permits BMP signaling in the early Drosophila embryo. Bornemann DJ, et al. Development, 2008 Mar. PMID 18256192, Free PMC Article
  4. Glycosylation of proteins in plants and invertebrates. Wilson IB. Curr Opin Struct Biol, 2002 Oct. PMID 12464307
  5. Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila. Caizzi R, et al. PLoS Genet, 2016 Aug. PMID 27513559, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables galactosylxylosylprotein 3-beta-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosylxylosylprotein 3-beta-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycosaminoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosaminoglycan biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
beta-1,3-Galactosyltransferase II
Names
CG8734-PA
beta3GalTII-PA
galactosyltransferase II
NP_610399.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8626181..8627611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136555.3 → NP_610399.1  beta-1,3-Galactosyltransferase II [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610399.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7G9, Q4V698
    Related
    FBpp0087807
    Conserved Domains (1) summary
    cl21608
    Location:125 → 319
    Galactosyl_T; Galactosyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7G9 A1Z7G9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous