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Cbr4 carbonyl reductase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 359725, updated on 5-Mar-2024

Summary

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Symbol
Cbr4provided by RGD
Full Name
carbonyl reductase 4provided by RGD
Primary source
RGD:727826
See related
Ensembl:ENSRNOG00000024411 AllianceGenome:RGD:727826
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Predicted to be involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Predicted to be located in mitochondrial matrix. Predicted to be part of oxidoreductase complex. Orthologous to human CBR4 (carbonyl reductase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 179.2), Heart (RPKM 178.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cbr4 in Genome Data Viewer
Location:
16p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (33625734..33695067, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (28629928..28684230, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (31944328..31972553, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097508 Neighboring gene palladin, cytoskeletal associated protein Neighboring gene uncharacterized LOC120097383 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482542 Neighboring gene SH3 domain containing ring finger 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase. Endo S, et al. Biochem Biophys Res Commun, 2008 Dec 26. PMID 19000905
  2. Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. Venkatesan R, et al. Nat Commun, 2014 Sep 9. PMID 25203508
  3. Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin. Bains OS, et al. J Pharmacol Exp Ther, 2010 Dec. PMID 20837989
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC105271

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD(P)H dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables NADPH binding IEA
Inferred from Electronic Annotation
more info
  
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
  
enables NADPH binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NADPH dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables NADPH dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables NADPH dehydrogenase (quinone) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables quinone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
enables quinone binding ISO
Inferred from Sequence Orthology
more info
  
enables quinone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in daunorubicin metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in daunorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in doxorubicin metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in doxorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein heterotetramerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein heterotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of oxidoreductase complex IEA
Inferred from Electronic Annotation
more info
  
part_of oxidoreductase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oxidoreductase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
3-oxoacyl-[acyl-carrier-protein] reductase
Names
3-ketoacyl-[acyl-carrier-protein] reductase beta subunit
KAR beta subunit
carbonic reductase 4
carbonyl reductase family member 4
quinone reductase CBR4
NP_872613.1
XP_038950534.1
XP_038950535.1
XP_038950537.1
XP_063131549.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182672.2 → NP_872613.1  3-oxoacyl-[acyl-carrier-protein] reductase

    See identical proteins and their annotated locations for NP_872613.1

    Status: PROVISIONAL

    Source sequence(s)
    AY305858
    UniProtKB/Swiss-Prot
    Q7TS56
    UniProtKB/TrEMBL
    A0A8I6A1W1, A6KIR4
    Related
    ENSRNOP00000038351.6, ENSRNOT00000032199.7
    Conserved Domains (1) summary
    cl21454
    Location:3 → 232
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    33625734..33695067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275479.1 → XP_063131549.1  3-oxoacyl-[acyl-carrier-protein] reductase isoform X1

  2. XM_039094606.2 → XP_038950534.1  3-oxoacyl-[acyl-carrier-protein] reductase isoform X2

    UniProtKB/TrEMBL
    A6KIR6
    Conserved Domains (1) summary
    cl21454
    Location:2 → 163
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_039094609.2 → XP_038950537.1  3-oxoacyl-[acyl-carrier-protein] reductase isoform X2

    UniProtKB/TrEMBL
    A6KIR6
    Conserved Domains (1) summary
    cl21454
    Location:2 → 163
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. XM_039094607.2 → XP_038950535.1  3-oxoacyl-[acyl-carrier-protein] reductase isoform X2

    UniProtKB/TrEMBL
    A6KIR6
    Conserved Domains (1) summary
    cl21454
    Location:2 → 163
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TS56.1 GenPept UniProtKB/Swiss-Prot:Q7TS56

Gene LinkOut

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