Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs |
PubMed
|
Nef
|
nef
|
IL-1beta, IL-12, and IL-15 are factors involved in the upregulation of IFN-gamma expression in coculture between Nef-pulsed iDCs and NK cells |
PubMed
|
|
nef
|
Exogenous HIV-1 Nef protein induces the proliferation of unstimulated and suboptimally stimulated normal human PBMC through upregulation of IL-15 synthesis in the monocyte/macrophage population |
PubMed
|
Tat
|
tat
|
HIV-1 Tat upregulates the expression of interleukin 15 (IL15) gene in mammary epithelial cells |
PubMed
|
capsid
|
gag
|
Unactivated memory CD4+ T cells infected by HIV-1 in the presence of IL-2 and IL-15 alone or IL-6/IL-7/TNF-alpha combination, upregulate granzyme B and HIV-1 CA production |
PubMed
|
integrase
|
gag-pol
|
Treatment of resting CD4+ T cells with cytokines IL-2, IL-4, IL-7, or IL15 enhances HIV-1 IN mutant D116N to generate de novo virus production |
PubMed
|
matrix
|
gag
|
HIV-1 Matrix is able to reduce MIP-1alpha secretion from IL-15-stimulated monocyte cells |
PubMed
|
|
gag
|
HIV-1 Matrix slightly enhances TNF-alpha and IFN-gamma secretion induced by IL-15 monocyte stimulation and counteracts IL-4 mediated inhibition of the production of these cytokines |
PubMed
|
|
gag
|
HIV-1 Matrix upregulates levels of IL-2, IL-12 and IL-15 in natural killer cells and induces natural killer cell proliferation |
PubMed
|
Go to the HIV-1, Human Interaction Database