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Zfp422 zinc finger protein 422 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360389, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp422provided by RGD
Official Full Name
zinc finger protein 422provided by RGD
Primary source
RGD:620229
See related
Ensembl:ENSRNOG00000013379 AllianceGenome:RGD:620229
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kox15; Znf22; Krox-25
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human ZNF22 (zinc finger protein 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 93.2), Heart (RPKM 86.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp422 in Genome Data Viewer
Location:
4q42
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (151558254..151565730, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (149885805..149893287, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (148757362..148761594, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily D member 15B Neighboring gene transfer RNA cysteine (anticodon GCA) 29 Neighboring gene Ras association domain family member 4 Neighboring gene DEPP autophagy regulator 1 Neighboring gene transmembrane protein 72

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Developmental expression pattern and DNA-binding properties of the zinc finger transcription factor Krox-26. Teo W, et al. Connect Tissue Res, 2003. PMID 12952191
  2. Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25. Lee SK, et al. Genomics, 2004 Feb. PMID 14706453
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC105332

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in odontogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 22
Names
krueppel-type zinc finger protein Krox-25
zinc finger protein 22 (KOX 15)
zinc finger protein Krox-25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012745.1 → NP_001012763.1  zinc finger protein 22

    See identical proteins and their annotated locations for NP_001012763.1

    Status: PROVISIONAL

    Source sequence(s)
    BC090354
    UniProtKB/Swiss-Prot
    Q5EAN1, Q9ERU2
    UniProtKB/TrEMBL
    A6IL24
    Conserved Domains (2) summary
    COG5048
    Location:53 → 192
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:113 → 133
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    151558254..151565730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107733.2 → XP_038963661.1  zinc finger protein 22 isoform X1

    UniProtKB/Swiss-Prot
    Q5EAN1, Q9ERU2
    UniProtKB/TrEMBL
    A6IL24
    Related
    ENSRNOP00000018050.4
    Conserved Domains (2) summary
    COG5048
    Location:53 → 192
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:113 → 133
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006237189.5 → XP_006237251.1  zinc finger protein 22 isoform X1

    See identical proteins and their annotated locations for XP_006237251.1

    UniProtKB/Swiss-Prot
    Q5EAN1, Q9ERU2
    UniProtKB/TrEMBL
    A6IL24
    Related
    ENSRNOP00000085999.1
    Conserved Domains (2) summary
    COG5048
    Location:53 → 192
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:113 → 133
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_006237187.5 → XP_006237249.1  zinc finger protein 22 isoform X1

    See identical proteins and their annotated locations for XP_006237249.1

    UniProtKB/Swiss-Prot
    Q5EAN1, Q9ERU2
    UniProtKB/TrEMBL
    A6IL24
    Related
    ENSRNOP00000076367.1
    Conserved Domains (2) summary
    COG5048
    Location:53 → 192
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:113 → 133
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_006237190.5 → XP_006237252.1  zinc finger protein 22 isoform X1

    See identical proteins and their annotated locations for XP_006237252.1

    UniProtKB/Swiss-Prot
    Q5EAN1, Q9ERU2
    UniProtKB/TrEMBL
    A6IL24
    Conserved Domains (2) summary
    COG5048
    Location:53 → 192
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:113 → 133
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERU2.2 GenPept UniProtKB/Swiss-Prot:Q9ERU2

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