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Zc3h7a zinc finger CCCH type containing 7 A [ Rattus norvegicus (Norway rat) ]

Gene ID: 360466, updated on 11-Apr-2024

Summary

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Symbol
Zc3h7aprovided by RGD
Full Name
zinc finger CCCH type containing 7 Aprovided by RGD
Primary source
RGD:1311225
See related
Ensembl:ENSRNOG00000002420 AllianceGenome:RGD:1311225
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zc3hdc7
Summary
Predicted to enable miRNA binding activity. Predicted to be involved in production of miRNAs involved in gene silencing by miRNA. Orthologous to human ZC3H7A (zinc finger CCCH-type containing 7A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 242.7), Spleen (RPKM 187.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zc3h7a in Genome Data Viewer
Location:
10q11
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (4980147..5019637)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (4473177..4512668)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (4535651..4575643)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100911627 Neighboring gene ribosomal L1 domain containing 1 Neighboring gene uncharacterized LOC134480745 Neighboring gene thioredoxin domain containing 11 Neighboring gene BCL2 like 12, pseudogene 2 Neighboring gene stannin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Treiber T, et al. Mol Cell, 2017 Apr 20. PMID 28431233
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger CCCH domain-containing protein 7A
Names
zinc finger CCCH type domain containing 7
zinc finger CCCH-type containing 7A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108262.2 → NP_001101732.2  zinc finger CCCH domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D3ZP12
    Related
    ENSRNOP00000003309.7, ENSRNOT00000003309.8
    Conserved Domains (4) summary
    TIGR00990
    Location:46 → 169
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00020
    Location:859 → 881
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:46 → 71
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:857 → 882
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    4980147..5019637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269282.1 → XP_063125352.1  zinc finger CCCH domain-containing protein 7A isoform X2

  2. XM_008767490.4 → XP_008765712.1  zinc finger CCCH domain-containing protein 7A isoform X1

    See identical proteins and their annotated locations for XP_008765712.1

    UniProtKB/TrEMBL
    D3ZP12
    Conserved Domains (4) summary
    TIGR00990
    Location:46 → 169
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00020
    Location:859 → 881
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:46 → 71
    TPR; TPR repeat [structural motif]
    pfam12171
    Location:857 → 882
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  3. XM_063269280.1 → XP_063125350.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/TrEMBL
    D3ZP12

  4. XM_063269281.1 → XP_063125351.1  zinc finger CCCH domain-containing protein 7A isoform X1

    UniProtKB/TrEMBL
    D3ZP12

  5. XM_039086257.2 → XP_038942185.1  zinc finger CCCH domain-containing protein 7A isoform X3

    Conserved Domains (2) summary
    sd00020
    Location:468 → 490
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:466 → 491
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

RNA

  1. XR_594546.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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