Tada2a transcriptional adaptor 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tada2aprovided by RGD
Official Full Name: transcriptional adaptor 2Aprovided by RGD
Primary source: RGD:1309959
See related: Ensembl:ENSRNOG00000002757 AllianceGenome:RGD:1309959
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tada2l
Summary: Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in several processes, including chromatin remodeling; histone H3 acetylation; and positive regulation of histone acetylation. Predicted to act upstream of or within mitotic cell cycle; regulation of protein modification process; and regulation of protein stability. Predicted to be located in mitotic spindle. Predicted to be part of ATAC complex and SAGA complex. Predicted to be active in nucleus. Orthologous to human TADA2A (transcriptional adaptor 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 105.5), Brain (RPKM 87.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (69463966..69511612, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (68966502..69014149, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (71393701..71441435, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU046428 (e-PCR)
- UniSTS:111452

RH139765 (e-PCR)
- UniSTS:221849

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	IEA Inferred from Electronic Annotation more info
involved_in regulation of embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of tubulin deacetylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ATAC complex	IEA Inferred from Electronic Annotation more info
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
part_of SAGA complex	ISO Inferred from Sequence Orthology more info
part_of SAGA-type complex	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcriptional adapter 2-alpha

Names: ADA2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012141.1 → NP_001012141.1 transcriptional adapter 2-alpha

See identical proteins and their annotated locations for NP_001012141.1

Status: PROVISIONAL

Source sequence(s)

BC079084

UniProtKB/Swiss-Prot

A1EC76, Q6AYE3

UniProtKB/TrEMBL

A0A8I6ABC7

Related

ENSRNOP00000003699.5, ENSRNOT00000003699.6

Conserved Domains (1) summary

COG5114
Location:28 → 440

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

69463966..69511612 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247041.4 → XP_006247103.1 transcriptional adapter 2-alpha isoform X2

UniProtKB/TrEMBL

A0A0G2K0R7, A0A8I6ABC7

Related

ENSRNOP00000071555.2, ENSRNOT00000087769.2

Conserved Domains (4) summary

COG5114
Location:28 → 420

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd00167
Location:54 → 98

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam04433
Location:354 → 420

SWIRM; SWIRM domain

cl00295
Location:15 → 44

ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
XM_063269382.1 → XP_063125452.1 transcriptional adapter 2-alpha isoform X7
XM_039086364.2 → XP_038942292.1 transcriptional adapter 2-alpha isoform X6

Conserved Domains (1) summary

COG5114
Location:28 → 320

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
XM_039086363.1 → XP_038942291.1 transcriptional adapter 2-alpha isoform X4

UniProtKB/TrEMBL

A0A8L2UHP0

Conserved Domains (1) summary

COG5114
Location:4 → 396

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
XM_006247042.4 → XP_006247104.1 transcriptional adapter 2-alpha isoform X3

UniProtKB/TrEMBL

A0A8L2UHP0

Related

ENSRNOP00000089252.1, ENSRNOT00000119062.1

Conserved Domains (4) summary

COG5114
Location:4 → 416

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd00167
Location:50 → 94

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02335
Location:3 → 40

ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam04433
Location:350 → 416

SWIRM; SWIRM domain
XM_039086362.2 → XP_038942290.1 transcriptional adapter 2-alpha isoform X1

UniProtKB/Swiss-Prot

A1EC76, Q6AYE3

UniProtKB/TrEMBL

A0A8I6ABC7

Conserved Domains (1) summary

COG5114
Location:28 → 440

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
XM_039086365.2 → XP_038942293.1 transcriptional adapter 2-alpha isoform X8

Conserved Domains (1) summary

COG5114
Location:1 → 276

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
XM_063269381.1 → XP_063125451.1 transcriptional adapter 2-alpha isoform X5