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Dhrs11 dehydrogenase/reductase 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360583, updated on 5-Mar-2024

Summary

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Official Symbol
Dhrs11provided by RGD
Official Full Name
dehydrogenase/reductase 11provided by RGD
Primary source
RGD:1307935
See related
Ensembl:ENSRNOG00000027891 AllianceGenome:RGD:1307935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307935
Summary
Predicted to enable 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 17-beta-ketosteroid reductase activity; and 3-keto sterol reductase activity. Predicted to be involved in steroid biosynthetic process. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 174.8), Heart (RPKM 164.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q26
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70195637..70205735, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69698214..69708294, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72144042..72153496, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480634 Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 4 Neighboring gene mitochondrial rRNA methyltransferase 1 Neighboring gene gametogenetin binding protein 2 Neighboring gene zinc finger, HIT-type containing 3 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class W

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenase. Endo S, et al. Biochem Biophys Res Commun, 2016 Mar 25. PMID 26920053
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables 17-beta-ketosteroid reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3-keto sterol reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dehydrogenase/reductase SDR family member 11
Names
dehydrogenase/reductase (SDR family) member 11
NP_001014141.2
XP_008766291.3
XP_038942294.1
XP_038942295.1
XP_038942296.2
XP_038942300.1
XP_063125454.1
XP_063125455.1
XP_063125456.1
XP_063125457.1
XP_063125458.1
XP_063125460.1
XP_063125461.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014119.2 → NP_001014141.2  dehydrogenase/reductase SDR family member 11

    See identical proteins and their annotated locations for NP_001014141.2

    Status: VALIDATED

    Source sequence(s)
    BC088444, DY311021
    UniProtKB/TrEMBL
    A6HHL9
    Conserved Domains (2) summary
    cd05343
    Location:6 → 256
    Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs
    COG4221
    Location:6 → 259
    YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    70195637..70205735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086368.2 → XP_038942296.2  dehydrogenase/reductase SDR family member 11 isoform X9

  2. XM_008768069.4 → XP_008766291.3  dehydrogenase/reductase SDR family member 11 isoform X3

  3. XM_063269385.1 → XP_063125455.1  dehydrogenase/reductase SDR family member 11 isoform X2

  4. XM_039086366.2 → XP_038942294.1  dehydrogenase/reductase SDR family member 11 isoform X4

    UniProtKB/TrEMBL
    G3V978
    Related
    ENSRNOP00000038582.4
    Conserved Domains (1) summary
    cd05343
    Location:76 → 295
    Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs

  5. XM_063269384.1 → XP_063125454.1  dehydrogenase/reductase SDR family member 11 isoform X1

  6. XM_063269390.1 → XP_063125460.1  dehydrogenase/reductase SDR family member 11 isoform X10

  7. XM_039086372.2 → XP_038942300.1  dehydrogenase/reductase SDR family member 11 isoform X12

    Conserved Domains (2) summary
    PRK07985
    Location:31 → 109
    PRK07985; SDR family oxidoreductase
    cl21454
    Location:76 → 171
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  8. XM_063269387.1 → XP_063125457.1  dehydrogenase/reductase SDR family member 11 isoform X6

  9. XM_039086367.2 → XP_038942295.1  dehydrogenase/reductase SDR family member 11 isoform X7

    Conserved Domains (1) summary
    cl21454
    Location:6 → 186
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  10. XM_063269388.1 → XP_063125458.1  dehydrogenase/reductase SDR family member 11 isoform X8

  11. XM_063269386.1 → XP_063125456.1  dehydrogenase/reductase SDR family member 11 isoform X5

  12. XM_063269391.1 → XP_063125461.1  dehydrogenase/reductase SDR family member 11 isoform X11

Nucleotide Protein Strain
Heading Accession and Version

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