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Etv4 ETS variant transcription factor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360635, updated on 3-Apr-2024

Summary

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Official Symbol
Etv4provided by RGD
Official Full Name
ETS variant transcription factor 4provided by RGD
Primary source
RGD:1306524
See related
Ensembl:ENSRNOG00000020792 AllianceGenome:RGD:1306524
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pea3
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; positive regulation of keratinocyte differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including branching involved in mammary gland duct morphogenesis; motor neuron axon guidance; and negative regulation of mammary gland epithelial cell proliferation. Predicted to be located in chromosome and nucleolus. Predicted to be active in nucleus. Orthologous to human ETV4 (ETS variant transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 38.1), Brain (RPKM 20.8) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Etv4 in Genome Data Viewer
Location:
10q32.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87206977..87222202, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86706749..86721974, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89685058..89700300, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Sin3A associated protein 18, pseudogene 1 Neighboring gene DEAH-box helicase 8 Neighboring gene RNA polymerase II, I and III subunit L, pseudogene 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit V3, pseudogene 2 Neighboring gene uncharacterized LOC102546527

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation. Kandemir B, et al. Neurosci Lett, 2020 Nov 1. PMID 32891673
  2. Suppression subtractive hybridization analysis of gene expression during late kidney development identifies the developmentally regulated gene rPEA3. Chen Q, et al. Nephron Exp Nephrol, 2009. PMID 19293599
  3. PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells. Perez A, et al. J Biol Chem, 2003 Sep 19. PMID 12855694
  4. ETS gene Pea3 controls the central position and terminal arborization of specific motor neuron pools. Livet J, et al. Neuron, 2002 Aug 29. PMID 12372283
  5. Putative regulation of expression of members of the Ets variant 4 transcription factor family and their downstream targets in the rat epididymis. Yang L, et al. Biol Reprod, 2006 Apr. PMID 16394217

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation.
    Title: Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation.
  2. This study demonstrates that Etv4 and Etv5 transcription factors are expressed in hippocampal pyramidal neurons during the main period of dendritogenesis; reveals a novel role for Etv4 and Etv5 transcription factors for hippocampal circuit development and the coordination of synaptic maturation; and indicates that both factors are essential in the transcriptional program linking BDNF signaling to dendrite development.
    Title: Pea3 Transcription Factors, Etv4 and Etv5, Are Required for Proper Hippocampal Dendrite Development and Plasticity.
  3. these data establish Etv4 and Etv5 as essential molecules of the transcriptional program linking neurotrophin signaling to sensory neuronal differentiation
    Title: Pea3 transcription factor family members Etv4 and Etv5 mediate retrograde signaling and axonal growth of DRG sensory neurons in response to NGF.
  4. Newly identified gene rat PEA3 may play an important role in kidney development and differentiation.
    Title: Suppression subtractive hybridization analysis of gene expression during late kidney development identifies the developmentally regulated gene rPEA3.
  5. The data suggest that ETV4 family members regulate their own expression, and that they regulate transcription of a subset of genes that are dependent upon testicular luminal fluid factors.
    Title: Putative regulation of expression of members of the Ets variant 4 transcription factor family and their downstream targets in the rat epididymis.
  6. expression of PEA3 in mammary tumors leads to up-regulation of Muc4/SMC transcription, the gene product of which may contribute to the metastatic potential of mammary tumors.
    Title: PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within motor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ETS translocation variant 4
Names
ets variant gene 4 (E1A enhancer binding protein, E1AF)
polyomavirus enhancer activator-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108299.1 → NP_001101769.1  ETS translocation variant 4

    See identical proteins and their annotated locations for NP_001101769.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HJF1, B5DF72, E9PTJ2
    Related
    ENSRNOP00000028213.4, ENSRNOT00000028213.7
    Conserved Domains (2) summary
    smart00413
    Location:343 → 426
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:7 → 341
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    87206977..87222202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768086.4 → XP_008766308.1  ETS translocation variant 4 isoform X3

    UniProtKB/TrEMBL
    B5DF72
    Conserved Domains (2) summary
    smart00413
    Location:384 → 467
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:53 → 382
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  2. XM_006247369.5 → XP_006247431.1  ETS translocation variant 4 isoform X2

    UniProtKB/TrEMBL
    B5DF72
    Conserved Domains (2) summary
    smart00413
    Location:390 → 473
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:53 → 388
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  3. XM_006247372.5 → XP_006247434.1  ETS translocation variant 4 isoform X4

    See identical proteins and their annotated locations for XP_006247434.1

    UniProtKB/TrEMBL
    B5DF72
    Conserved Domains (2) summary
    smart00413
    Location:344 → 427
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:7 → 342
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  4. XM_063269443.1 → XP_063125513.1  ETS translocation variant 4 isoform X1

  5. XM_039086407.2 → XP_038942335.1  ETS translocation variant 4 isoform X5

    UniProtKB/TrEMBL
    A6HJF1, B5DF72, E9PTJ2
    Conserved Domains (2) summary
    smart00413
    Location:343 → 426
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:7 → 341
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  6. XM_006247371.5 → XP_006247433.1  ETS translocation variant 4 isoform X4

    See identical proteins and their annotated locations for XP_006247433.1

    UniProtKB/TrEMBL
    B5DF72
    Related
    ENSRNOP00000070185.2
    Conserved Domains (2) summary
    smart00413
    Location:344 → 427
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:7 → 342
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  7. XM_006247370.5 → XP_006247432.1  ETS translocation variant 4 isoform X4

    See identical proteins and their annotated locations for XP_006247432.1

    UniProtKB/TrEMBL
    B5DF72
    Conserved Domains (2) summary
    smart00413
    Location:344 → 427
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:7 → 342
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  8. XM_017597400.3 → XP_017452889.2  ETS translocation variant 4 isoform X1

  9. XM_063269444.1 → XP_063125514.1  ETS translocation variant 4 isoform X7

  10. XM_039086410.2 → XP_038942338.1  ETS translocation variant 4 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AQD4, A6HJF2
    Related
    ENSRNOP00000096295.1
    Conserved Domains (2) summary
    smart00413
    Location:301 → 384
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:26 → 299
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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