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Kansl1 KAT8 regulatory NSL complex subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360642, updated on 2-May-2024

Summary

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Official Symbol
Kansl1provided by RGD
Official Full Name
KAT8 regulatory NSL complex subunit 1provided by RGD
Primary source
RGD:1311429
See related
Ensembl:ENSRNOG00000053680 AllianceGenome:RGD:1311429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311429
Summary
Predicted to enable histone acetyltransferase binding activity. Predicted to be involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Predicted to be located in nucleoplasm. Predicted to be part of MLL1 complex and NSL complex. Human ortholog(s) of this gene implicated in Koolen de Vries syndrome. Orthologous to human KANSL1 (KAT8 regulatory NSL complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 168.0), Spleen (RPKM 137.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kansl1 in Genome Data Viewer
Location:
10q32.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (89737637..89868620, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (89237667..89368735, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (92388045..92517449, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein tau Neighboring gene uncharacterized LOC134480886 Neighboring gene uncharacterized LOC134480887 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene cell division cycle 27 Neighboring gene myosin, light chain 4 Neighboring gene glutathione S-transferase pi 1, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. Cai Y, et al. J Biol Chem, 2010 Feb 12. PMID 20018852, Free PMC Article
  2. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Dou Y, et al. Cell, 2005 Jun 17. PMID 15960975
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone acetyltransferase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NSL complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
KAT8 regulatory NSL complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427727.1 → NP_001414656.1  KAT8 regulatory NSL complex subunit 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6AJF7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    89737637..89868620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269456.1 → XP_063125526.1  KAT8 regulatory NSL complex subunit 1 isoform X4

  2. XM_063269453.1 → XP_063125523.1  KAT8 regulatory NSL complex subunit 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ACX3

  3. XM_063269454.1 → XP_063125524.1  KAT8 regulatory NSL complex subunit 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K8Z6

  4. XM_063269452.1 → XP_063125522.1  KAT8 regulatory NSL complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AJF7
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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