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Sec14l1 SEC14-like lipid binding 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360668, updated on 11-Apr-2024

Summary

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Official Symbol
Sec14l1provided by RGD
Official Full Name
SEC14-like lipid binding 1provided by RGD
Primary source
RGD:1563123
See related
Ensembl:ENSRNOG00000002722 AllianceGenome:RGD:1563123
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563123
Summary
Predicted to enable RIG-I binding activity. Predicted to be involved in choline transport and negative regulation of RIG-I signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to colocalize with Golgi apparatus. Orthologous to human SEC14L1 (SEC14 like lipid binding 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 201.0), Adrenal (RPKM 168.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sec14l1 in Genome Data Viewer
Location:
10q32.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102818693..102865841)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (102319920..102367070)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (106065712..106112859)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Neighboring gene uncharacterized LOC100912002 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene ribosomal protein L12, pseudogene 9 Neighboring gene uncharacterized LOC102547461 Neighboring gene septin 9 Neighboring gene uncharacterized LOC134480908 Neighboring gene uncharacterized LOC134480724

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1. Li MT, et al. J Virol, 2013 Sep. PMID 23843640, Free PMC Article
  2. SEC14-like protein 1 interacts with cholinergic transporters. Ribeiro FM, et al. Neurochem Int, 2007 Jan. PMID 17092608
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RIG-I binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RIG-I binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in choline transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of RIG-I signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SEC14-like protein 1
Names
SEC14-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108309.1 → NP_001101779.1  SEC14-like protein 1

    See identical proteins and their annotated locations for NP_001101779.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A8I5ZQG0, A6HL08, D3ZKG3
    Related
    ENSRNOP00000003690.4, ENSRNOT00000003690.6
    Conserved Domains (3) summary
    smart01100
    Location:257 → 302
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:327 → 491
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:17 → 173
    PRELI; PRELI-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    102818693..102865841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269479.1 → XP_063125549.1  SEC14-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZVS7

  2. XM_017597412.3 → XP_017452901.1  SEC14-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQG0, A6HL08, D3ZKG3
    Conserved Domains (3) summary
    smart01100
    Location:257 → 302
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:327 → 491
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:17 → 173
    PRELI; PRELI-like family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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