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Mcrip1 MAPK regulated co-repressor interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360677, updated on 3-Apr-2024

Summary

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Official Symbol
Mcrip1provided by RGD
Official Full Name
MAPK regulated co-repressor interacting protein 1provided by RGD
Primary source
RGD:1311925
See related
AllianceGenome:RGD:1311925
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam195b; RGD1311925
Summary
Predicted to be involved in regulation of epithelial to mesenchymal transition. Predicted to be located in cytoplasmic stress granule and nucleus. Orthologous to human MCRIP1 (MAPK regulated corepressor interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 71.4), Kidney (RPKM 67.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mcrip1 in Genome Data Viewer
Location:
10q32.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106318985..106326442, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105820656..105828146, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109720144..109727595, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 10 Neighboring gene uncharacterized LOC103693493 Neighboring gene glucagon receptor Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 like 1 Neighboring gene protein phosphatase 1, regulatory subunit 27 Neighboring gene prolyl 4-hydroxylase subunit beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP. Ichikawa K, et al. Mol Cell, 2015 Apr 2. PMID 25728771
  2. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. Bish R, et al. Biomolecules, 2015 Jul 15. PMID 26184334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
mapk-regulated corepressor-interacting protein 1
Names
family with sequence similarity 195, member B
protein FAM195B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108311.1 → NP_001101781.1  mapk-regulated corepressor-interacting protein 1

    See identical proteins and their annotated locations for NP_001101781.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/Swiss-Prot
    B0BN72
    Conserved Domains (1) summary
    pfam14799
    Location:4 → 93
    FAM195; FAM195 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    106318985..106326442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269481.1 → XP_063125551.1  mapk-regulated corepressor-interacting protein 1 isoform X2

  2. XM_017597414.3 → XP_017452903.1  mapk-regulated corepressor-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B0BN72
    Conserved Domains (1) summary
    pfam14799
    Location:4 → 93
    FAM195; FAM195 family

  3. XM_006247896.5 → XP_006247958.1  mapk-regulated corepressor-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006247958.1

    UniProtKB/Swiss-Prot
    B0BN72
    Conserved Domains (1) summary
    pfam14799
    Location:4 → 93
    FAM195; FAM195 family

  4. XM_039086443.2 → XP_038942371.1  mapk-regulated corepressor-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B0BN72
    Conserved Domains (1) summary
    pfam14799
    Location:4 → 93
    FAM195; FAM195 family

  5. XM_017597415.3 → XP_017452904.1  mapk-regulated corepressor-interacting protein 1 isoform X2

    Conserved Domains (1) summary
    pfam14799
    Location:1 → 88
    FAM195; FAM195 family

  6. XM_063269482.1 → XP_063125552.1  mapk-regulated corepressor-interacting protein 1 isoform X2

  7. XM_063269480.1 → XP_063125550.1  mapk-regulated corepressor-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B0BN72
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0BN72.1 GenPept UniProtKB/Swiss-Prot:B0BN72

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