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Narf nuclear prelamin A recognition factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 360681, updated on 2-May-2024

Summary

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Symbol
Narfprovided by RGD
Full Name
nuclear prelamin A recognition factorprovided by RGD
Primary source
RGD:1310894
See related
Ensembl:ENSRNOG00000036664 AllianceGenome:RGD:1310894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310894
Summary
Predicted to enable lamin binding activity. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in lamin filament. Orthologous to human NARF (nuclear prelamin A recognition factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 273.4), Thymus (RPKM 191.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Narf in Genome Data Viewer
Location:
10q32.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (107017344..107035777)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106519508..106537494)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (110445765..110463735)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene hexosaminidase D Neighboring gene cytochrome b-245 chaperone 1 Neighboring gene phosphoglycerate mutase 1, pseudogene 1 Neighboring gene uncharacterized LOC134480920 Neighboring gene forkhead box K2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Prenylated prelamin A interacts with Narf, a novel nuclear protein. Barton RM, et al. J Biol Chem, 1999 Oct 15. PMID 10514485
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC125093

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lamin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lamin binding IEA
Inferred from Electronic Annotation
more info
  
enables lamin binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in lamin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamin filament IEA
Inferred from Electronic Annotation
more info
  
located_in lamin filament ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear lumen ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear prelamin A recognition factor
Names
IOP2
iron-only hydrogenase-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039207.2 → NP_001034296.1  nuclear prelamin A recognition factor

    See identical proteins and their annotated locations for NP_001034296.1

    Status: VALIDATED

    Source sequence(s)
    BC090020, BC110050
    UniProtKB/Swiss-Prot
    Q2YDU6
    UniProtKB/TrEMBL
    A0A8I5ZR12
    Related
    ENSRNOP00000051803.3, ENSRNOT00000054920.3
    Conserved Domains (3) summary
    smart00902
    Location:398 → 446
    Fe_hyd_SSU; Iron hydrogenase small subunit
    COG4624
    Location:43 → 443
    Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]
    pfam02906
    Location:92 → 384
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    107017344..107035777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597416.3 → XP_017452905.1  nuclear prelamin A recognition factor isoform X2

    UniProtKB/TrEMBL
    A0A8L2QR57

  2. XM_006247899.5 → XP_006247961.1  nuclear prelamin A recognition factor isoform X1

    UniProtKB/TrEMBL
    A0A8L2QR57
    Conserved Domains (2) summary
    TIGR02512
    Location:39 → 422
    FeFe_hydrog_A; [FeFe] hydrogenase, group A
    pfam02906
    Location:129 → 412
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2YDU6.1 GenPept UniProtKB/Swiss-Prot:Q2YDU6

Gene LinkOut

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