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Cip2a cellular inhibitor of PP2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 360711, updated on 11-Apr-2024

Summary

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Official Symbol
Cip2aprovided by RGD
Official Full Name
cellular inhibitor of PP2Aprovided by RGD
Primary source
RGD:1310335
See related
Ensembl:ENSRNOG00000039183 AllianceGenome:RGD:1310335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310335
Summary
Predicted to enable protein homodimerization activity. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation and spermatogenesis. Predicted to be located in cytosol and plasma membrane. Orthologous to human CIP2A (cellular inhibitor of PP2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 50.7), Spleen (RPKM 35.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cip2a in Genome Data Viewer
Location:
11q21
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (65255123..65285914, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (51792143..51823016, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (54373794..54404704, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene leukocyte surface antigen CD47-like Neighboring gene myosin, heavy chain 15 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene DAZ interacting zinc finger protein 3 Neighboring gene resistin-like gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice. Ventelä S, et al. PLoS One, 2012. PMID 22461891, Free PMC Article
  2. CIP2A increases self-renewal and is linked to Myc in neural progenitor cells. Kerosuo L, et al. Differentiation, 2010 Jul. PMID 20447748
  3. Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56. Wang J, et al. EMBO Rep, 2017 Mar. PMID 28174209, Free PMC Article
  4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in broken chromosome clustering IEA
Inferred from Electronic Annotation
more info
  
involved_in broken chromosome clustering ISO
Inferred from Sequence Orthology
more info
  
involved_in chromosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein CIP2A
Names
cell proliferation regulating inhibitor of protein phosphatase 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427687.2 → NP_001414616.1  protein CIP2A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    D3ZF50

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    65255123..65285914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088875.2 → XP_038944803.1  protein CIP2A isoform X1

    Conserved Domains (1) summary
    COG1196
    Location:302 → 552
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version

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