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Boc BOC cell adhesion associated, oncogene regulated [ Rattus norvegicus (Norway rat) ]

Gene ID: 360715, updated on 30-Mar-2024

Summary

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Official Symbol
Bocprovided by RGD
Official Full Name
BOC cell adhesion associated, oncogene regulatedprovided by RGD
Primary source
RGD:1304550
See related
Ensembl:ENSRNOG00000002041 AllianceGenome:RGD:1304550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in axon guidance; cell-cell adhesion; and positive regulation of myoblast differentiation. Predicted to act upstream of or within cell projection organization and smoothened signaling pathway. Located in axonal growth cone. Orthologous to human BOC (BOC cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 88.3), Heart (RPKM 82.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Boc in Genome Data Viewer
Location:
11q21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (69628703..69704009)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (56122697..56198060)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61084216..61159220)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693572 Neighboring gene uncharacterized LOC134481000 Neighboring gene uncharacterized LOC102552306 Neighboring gene cilia and flagella associated protein 44 Neighboring gene uncharacterized LOC120095657 Neighboring gene uncharacterized LOC134481069

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interactions between Hedgehog proteins and their binding partners come into view. Beachy PA, et al. Genes Dev, 2010 Sep 15. PMID 20844013, Free PMC Article
  2. Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc. Fabre PJ, et al. J Neurosci, 2010 Jan 6. PMID 20053908, Free PMC Article
  3. Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Zhang W, et al. Dev Cell, 2006 May. PMID 16647303
  4. BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. Kang JS, et al. EMBO J, 2002 Jan 15. PMID 11782431, Free PMC Article
  5. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, et al. Science, 2008 Sep 26. PMID 18772397, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell projection organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
brother of CDO
Names
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108317.2 → NP_001101787.2  brother of CDO precursor

    Status: VALIDATED

    Source sequence(s)
    CB324285, JAXUCZ010000011
    UniProtKB/TrEMBL
    D4A0Z7
    Related
    ENSRNOP00000002790.7, ENSRNOT00000002790.8
    Conserved Domains (7) summary
    smart00408
    Location:240 → 301
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:132 → 207
    IG; Immunoglobulin
    cd00063
    Location:601 → 692
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:480 → 554
    fn3; Fibronectin type III domain
    pfam07679
    Location:318 → 401
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:31 → 104
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:404 → 467
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    69628703..69704009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598158.3 → XP_017453647.1  brother of CDO isoform X1

    Conserved Domains (7) summary
    smart00408
    Location:332 → 393
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:132 → 207
    IG_like; Immunoglobulin like
    cd00063
    Location:601 → 692
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:318 → 401
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:468 → 554
    fn3; Fibronectin type III domain
    pfam16625
    Location:404 → 467
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cl11960
    Location:243 → 301
    Ig; Immunoglobulin domain

  2. XM_017598159.3 → XP_017453648.1  brother of CDO isoform X2

    UniProtKB/TrEMBL
    A6IR03
    Conserved Domains (7) summary
    smart00408
    Location:332 → 393
    IGc2; Immunoglobulin C-2 Type
    smart00060
    Location:468 → 552
    FN3; Fibronectin type 3 domain
    smart00410
    Location:132 → 207
    IG_like; Immunoglobulin like
    cd00063
    Location:600 → 691
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:318 → 401
    I-set; Immunoglobulin I-set domain
    pfam16625
    Location:404 → 467
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cl11960
    Location:243 → 301
    Ig; Immunoglobulin domain

  3. XM_017598160.3 → XP_017453649.1  brother of CDO isoform X3

    UniProtKB/TrEMBL
    D4A0Z7
    Conserved Domains (7) summary
    smart00408
    Location:332 → 393
    IGc2; Immunoglobulin C-2 Type
    smart00060
    Location:468 → 552
    FN3; Fibronectin type 3 domain
    smart00410
    Location:132 → 207
    IG_like; Immunoglobulin like
    cd00063
    Location:600 → 691
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:318 → 401
    I-set; Immunoglobulin I-set domain
    pfam16625
    Location:404 → 467
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cl11960
    Location:243 → 301
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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