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Pdia5 protein disulfide isomerase family A, member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360722, updated on 5-Mar-2024

Summary

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Symbol
Pdia5provided by RGD
Full Name
protein disulfide isomerase family A, member 5provided by RGD
Primary source
RGD:1359236
See related
Ensembl:ENSRNOG00000032327 AllianceGenome:RGD:1359236
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein disulfide isomerase activity and protein-disulfide reductase activity. Predicted to be involved in protein folding. Predicted to be located in endoplasmic reticulum lumen. Orthologous to human PDIA5 (protein disulfide isomerase family A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 130.4), Testes (RPKM 72.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pdia5 in Genome Data Viewer
Location:
11q22
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (78777436..78892370)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (65272152..65359087)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (68493035..68578999)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene semaphorin 5B Neighboring gene uncharacterized LOC120095662 Neighboring gene uncharacterized LOC120095661 Neighboring gene uncharacterized LOC120095660 Neighboring gene SEC22 homolog A, vesicle trafficking protein Neighboring gene uncharacterized LOC102551038 Neighboring gene adenylate cyclase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. pH dependence of the peptide thiol-disulfide oxidase activity of six members of the human protein disulfide isomerase family. Alanen HI, et al. Antioxid Redox Signal, 2006 Mar-Apr. PMID 16677074
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein disulfide-isomerase A5
Names
protein disulfide isomerase-associated 5
protein disulfide-isomerase A5-like
NP_001014147.1
XP_038944423.1
XP_038944424.1
XP_063126712.1
XP_063126713.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014125.1 → NP_001014147.1  protein disulfide-isomerase A5 precursor

    See identical proteins and their annotated locations for NP_001014147.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088305
    UniProtKB/Swiss-Prot
    Q5I0H9
    Related
    ENSRNOP00000059945.3, ENSRNOT00000067984.2
    Conserved Domains (3) summary
    cd02997
    Location:396 → 499
    PDI_a_PDIR; PDIa family, PDIR subfamily; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. Similar to PDI, it is involved ...
    cd03067
    Location:26 → 137
    PDI_b_PDIR_N; PDIb family, PDIR subfamily, N-terminal TRX-like b domain; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. ...
    TIGR01130
    Location:166 → 501
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    78777436..78892370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270642.1 → XP_063126712.1  protein disulfide-isomerase A5 isoform X1

  2. XM_039088496.2 → XP_038944424.1  protein disulfide-isomerase A5 isoform X3

    UniProtKB/TrEMBL
    A6IRG4
    Conserved Domains (3) summary
    cd02997
    Location:150 → 254
    PDI_a_PDIR; PDIa family, PDIR subfamily; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. Similar to PDI, it is involved ...
    cd03067
    Location:26 → 137
    PDI_b_PDIR_N; PDIb family, PDIR subfamily, N-terminal TRX-like b domain; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. ...
    cl00388
    Location:275 → 323
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  3. XM_039088495.2 → XP_038944423.1  protein disulfide-isomerase A5 isoform X2

    Conserved Domains (2) summary
    cd02997
    Location:302 → 405
    PDI_a_PDIR; PDIa family, PDIR subfamily; composed of proteins similar to human PDIR (for Protein Disulfide Isomerase Related). PDIR is composed of three redox active TRX (a) domains and an N-terminal redox inactive TRX-like (b) domain. Similar to PDI, it is involved ...
    cl00388
    Location:1 → 43
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  4. XM_063270643.1 → XP_063126713.1  protein disulfide-isomerase A5 isoform X2

RNA

  1. XR_005491040.2 RNA Sequence

  2. XR_005491041.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I0H9.1 GenPept UniProtKB/Swiss-Prot:Q5I0H9

Gene LinkOut

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