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Snx4 sorting nexin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360725, updated on 6-Jun-2024

Summary

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Official Symbol
Snx4provided by RGD
Official Full Name
sorting nexin 4provided by RGD
Primary source
RGD:1309763
See related
Ensembl:ENSRNOG00000001786 AllianceGenome:RGD:1309763
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol binding activity and signaling receptor binding activity. Predicted to be involved in endocytic recycling; positive regulation of histamine secretion by mast cell; and protein transport. Predicted to be located in early endosome membrane and plasma membrane. Predicted to be part of SNARE complex and cytoplasmic dynein complex. Orthologous to human SNX4 (sorting nexin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 197.4), Brain (RPKM 166.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Snx4 in Genome Data Viewer
Location:
11q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (80965965..81023234, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (67460872..67518143, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (70693381..70753620, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 148 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene WAS/WASL-interacting protein family member 1-like Neighboring gene uncharacterized LOC120095666 Neighboring gene uncharacterized LOC134481083 Neighboring gene oxysterol binding protein-like 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment. Traer CJ, et al. Nat Cell Biol, 2007 Dec. PMID 17994011
  2. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Sander LE, et al. Eur J Immunol, 2008 Mar. PMID 18253931
  3. Identification of a family of sorting nexin molecules and characterization of their association with receptors. Haft CR, et al. Mol Cell Biol, 1998 Dec. PMID 9819414, Free PMC Article
  4. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. Parks WT, et al. J Biol Chem, 2001 Jun 1. PMID 11279102
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables leptin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of histamine secretion by mast cell ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic endosome ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sorting nexin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127550.1 → NP_001121022.1  sorting nexin-4

    See identical proteins and their annotated locations for NP_001121022.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166791
    UniProtKB/TrEMBL
    B2RYI6, E9PU13
    Related
    ENSRNOP00000002432.6, ENSRNOT00000002432.7
    Conserved Domains (3) summary
    cd06864
    Location:58 → 184
    PX_SNX4; The phosphoinositide binding Phox Homology domain of Sorting Nexin 4
    cd07622
    Location:205 → 448
    BAR_SNX4; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 4
    pfam11221
    Location:324 → 398
    Med21; Subunit 21 of Mediator complex

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    80965965..81023234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270646.1 → XP_063126716.1  sorting nexin-4 isoform X3

    UniProtKB/TrEMBL
    E9PU13

  2. XM_063270645.1 → XP_063126715.1  sorting nexin-4 isoform X2

    UniProtKB/TrEMBL
    E9PU13

  3. XM_063270644.1 → XP_063126714.1  sorting nexin-4 isoform X1

    UniProtKB/TrEMBL
    E9PU13

  4. XM_063270647.1 → XP_063126717.1  sorting nexin-4 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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