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Nek7 NIMA-related kinase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360850, updated on 13-Apr-2024

Summary

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Official Symbol
Nek7provided by RGD
Official Full Name
NIMA-related kinase 7provided by RGD
Primary source
RGD:1311160
See related
Ensembl:ENSRNOG00000000657 AllianceGenome:RGD:1311160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein serine/threonine kinase activity. Predicted to be involved in positive regulation of DNA metabolic process and protein phosphorylation. Predicted to be located in cytoplasm and nucleoplasm. Orthologous to human NEK7 (NIMA related kinase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 176.0), Heart (RPKM 130.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nek7 in Genome Data Viewer
Location:
13q13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (52573730..52700869, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (50022212..50149374, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (55485759..55617534, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit G3 Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma), pseudogene 2 Neighboring gene uncharacterized LOC120096259 Neighboring gene uncharacterized LOC120096260 Neighboring gene uncharacterized LOC134481500 Neighboring gene prothymosin alpha, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Reactive oxygen species induced by uric acid promote NRK‑52E cell apoptosis through the NEK7‑NLRP3 signaling pathway. Li D, et al. Mol Med Rep, 2021 Oct. PMID 34414459, Free PMC Article
  2. Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. Belham C, et al. Curr Biol, 2001 Aug 7. PMID 11516946
  3. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. Belham C, et al. J Biol Chem, 2003 Sep 12. PMID 12840024
  4. Anks3 alters the sub-cellular localization of the Nek7 kinase. Ramachandran H, et al. Biochem Biophys Res Commun, 2015 Aug 28. PMID 26188091
  5. High-throughput RNAi screening reveals novel regulators of telomerase. Cerone MA, et al. Cancer Res, 2011 May 1. PMID 21531765

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reactive oxygen species induced by uric acid promote NRK52E cell apoptosis through the NEK7NLRP3 signaling pathway.
    Title: Reactive oxygen species induced by uric acid promote NRK‑52E cell apoptosis through the NEK7‑NLRP3 signaling pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular function activator activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular function activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to potassium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to potassium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to potassium ion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NLRP3 inflammasome complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of telomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of telomere capping IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek7
Names
NIMA (never in mitosis gene a)-related expressed kinase 7
NIMA (never in mitosis gene a)-related kinase 7
never in mitosis A-related kinase 7
nimA-related protein kinase 7
NP_001101816.1
XP_063128539.1
XP_063128540.1
XP_063128541.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108346.3 → NP_001101816.1  serine/threonine-protein kinase Nek7

    See identical proteins and their annotated locations for NP_001101816.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    D3ZBE5
    UniProtKB/TrEMBL
    A0A0G2JUP0
    Related
    ENSRNOP00000000817.4, ENSRNOT00000000817.7
    Conserved Domains (1) summary
    cd08224
    Location:33 → 294
    STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    52573730..52700869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272470.1 → XP_063128540.1  serine/threonine-protein kinase Nek7 isoform X2

  2. XM_063272469.1 → XP_063128539.1  serine/threonine-protein kinase Nek7 isoform X1

    UniProtKB/Swiss-Prot
    D3ZBE5

  3. XM_063272471.1 → XP_063128541.1  serine/threonine-protein kinase Nek7 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZBE5.1 GenPept UniProtKB/Swiss-Prot:D3ZBE5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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