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Mpzl1 myelin protein zero-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360871, updated on 2-May-2024

Summary

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Symbol
Mpzl1provided by RGD
Full Name
myelin protein zero-like 1provided by RGD
Primary source
RGD:1359140
See related
Ensembl:ENSRNOG00000003248 AllianceGenome:RGD:1359140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in signal transduction. Predicted to act upstream of or within positive regulation of cell migration. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human MPZL1 (myelin protein zero like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 222.6), Uterus (RPKM 130.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mpzl1 in Genome Data Viewer
Location:
13q23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80385454..80422315, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (77852467..77889305, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83805244..83842074, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481587 Neighboring gene adenylate cyclase 10 Neighboring gene uncharacterized LOC134481588 Neighboring gene transfer RNA proline (anticodon AGG) 14 Neighboring gene transfer RNA proline (anticodon CGG) 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation. Roubelakis MG, et al. J Cell Biochem, 2007 Nov 1. PMID 17440960
  2. Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling. Zhao R, et al. J Biol Chem, 2002 Mar 8. PMID 11751924
  3. Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs. Zhao R, et al. J Biol Chem, 2000 Feb 25. PMID 10681522
  4. Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. Teckchandani A, et al. J Cell Biol, 2009 Jul 13. PMID 19581412, Free PMC Article
  5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93692

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myelin protein zero-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007728.2 → NP_001007729.1  myelin protein zero-like protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001007729.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q6AYT8
    UniProtKB/TrEMBL
    A0A8I6A952, A6IDH5
    Related
    ENSRNOP00000004376.4, ENSRNOT00000004376.6
    Conserved Domains (2) summary
    cd00096
    Location:38 → 42
    Ig; Ig strand A [structural motif]
    cl11960
    Location:38 → 154
    Ig; Immunoglobulin domain

  2. NM_001429783.1 → NP_001416712.1  myelin protein zero-like protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    80385454..80422315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250180.5 → XP_006250242.1  myelin protein zero-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9E7, A6IDH6, A6IDH7
    Related
    ENSRNOP00000088248.1
    Conserved Domains (2) summary
    cd05715
    Location:39 → 154
    Ig_P0-like; Immunoglobulin (Ig)-like domain of Protein zero (P0) and similar proteins
    smart00410
    Location:43 → 154
    IG_like; Immunoglobulin like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYT8.1 GenPept UniProtKB/Swiss-Prot:Q6AYT8

Gene LinkOut

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