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Tbc1d1 TBC1 domain family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360937, updated on 3-Apr-2024

Summary

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Official Symbol
Tbc1d1provided by RGD
Official Full Name
TBC1 domain family member 1provided by RGD
Primary source
RGD:1304562
See related
Ensembl:ENSRNOG00000002180 AllianceGenome:RGD:1304562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity. Involved in regulation of protein localization. Orthologous to human TBC1D1 (TBC1 domain family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 143.5), Kidney (RPKM 137.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p11
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (44289241..44489246, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (43936820..44135133, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (45598753..45797650, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481747 Neighboring gene uncharacterized LOC120096607 Neighboring gene uncharacterized LOC120096609 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene phosphoglucomutase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass. Paglialunga S, et al. Appl Physiol Nutr Metab, 2017 Jun. PMID 28177704
  2. Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats. Whitfield J, et al. J Biol Chem, 2017 Oct 6. PMID 28808062, Free PMC Article
  3. Expression, phosphorylation and function of the Rab-GTPase activating protein TBC1D1 in pancreatic beta-cells. Rütti S, et al. FEBS Lett, 2014 Jan 3. PMID 24239544
  4. EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells. Imai A, et al. J Biol Chem, 2011 Sep 30. PMID 21832089, Free PMC Article
  5. Increased AS160 phosphorylation, but not TBC1D1 phosphorylation, with increased postexercise insulin sensitivity in rat skeletal muscle. Funai K, et al. Am J Physiol Endocrinol Metab, 2009 Jul. PMID 19435856, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. fundamental role for TBC1D1 in maintaining in vivo beta-cell mass
    Title: The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass.
  2. results highlight a critical role for TBC1D1 in exercise tolerance and contraction-mediated translocation of GLUT4 to the plasma membrane in skeletal muscle.
    Title: Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats.
  3. Data show that TBC1D1 is expressed and phosphorylated in response to glucose in these cells.
    Title: Expression, phosphorylation and function of the Rab-GTPase activating protein TBC1D1 in pancreatic beta-cells.
  4. Significant differences found among the muscles for GLUT4 (2.5-fold), TUG (1.7-fold), RUVBL2 (2.0-fold), and TBC1D1 (2.7-fold), but not AS160.
    Title: Clustering of GLUT4, TUG, and RUVBL2 protein levels correlate with myosin heavy chain isoform pattern in skeletal muscles, but AS160 and TBC1D1 levels do not.
  5. EPI64 acted as a physiological Rab27-GAP that enhanced GTPase activity of Rab27 in response to IPR stimulation, and that this activity is required for IPR-induced amylase release.
    Title: EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells.
  6. Increased TBC1D1 phosphorylation may play a role in the insulin-independent increase in glucose transport postexercise.
    Title: Increased AS160 phosphorylation, but not TBC1D1 phosphorylation, with increased postexercise insulin sensitivity in rat skeletal muscle.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
TBC1 domain family member 1
Names
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427317.1 → NP_001414246.1  TBC1 domain family member 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I5ZMX5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    44289241..44489246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251004.5 → XP_006251066.1  TBC1 domain family member 1 isoform X1

    See identical proteins and their annotated locations for XP_006251066.1

    UniProtKB/TrEMBL
    A0A8I5ZLK4, A0A8I5ZMX5
    Related
    ENSRNOP00000079436.1
    Conserved Domains (4) summary
    smart00164
    Location:886 → 1103
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd00934
    Location:21 → 150
    PTB; Phosphotyrosine-binding (PTB) PH-like fold
    cd01269
    Location:164 → 365
    PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
    pfam11830
    Location:784 → 834
    DUF3350; Domain of unknown function (DUF3350)

  2. XM_341215.10 → XP_341216.4  TBC1 domain family member 1 isoform X3

    See identical proteins and their annotated locations for XP_341216.4

    UniProtKB/TrEMBL
    A0A8I5ZLK4, A0A8I6AB45
    Related
    ENSRNOP00000088613.1
    Conserved Domains (4) summary
    smart00164
    Location:791 → 1008
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd00934
    Location:21 → 150
    PTB; Phosphotyrosine-binding (PTB) PH-like fold
    cd01269
    Location:164 → 365
    PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
    pfam11830
    Location:689 → 739
    DUF3350; Domain of unknown function (DUF3350)

  3. XM_006251005.5 → XP_006251067.1  TBC1 domain family member 1 isoform X2

    See identical proteins and their annotated locations for XP_006251067.1

    UniProtKB/TrEMBL
    A0A8I5ZLK4, A0A8I6G5Y5
    Related
    ENSRNOP00000079959.1
    Conserved Domains (4) summary
    smart00164
    Location:831 → 1048
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd00934
    Location:21 → 150
    PTB; Phosphotyrosine-binding (PTB) PH-like fold
    cd01269
    Location:164 → 365
    PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
    pfam11830
    Location:729 → 779
    DUF3350; Domain of unknown function (DUF3350)

  4. XM_063273343.1 → XP_063129413.1  TBC1 domain family member 1 isoform X6

    UniProtKB/TrEMBL
    D4AC16

  5. XM_063273342.1 → XP_063129412.1  TBC1 domain family member 1 isoform X5

  6. XM_006251006.4 → XP_006251068.1  TBC1 domain family member 1 isoform X4

    See identical proteins and their annotated locations for XP_006251068.1

    UniProtKB/TrEMBL
    A0A8I5ZLK4
    Related
    ENSRNOP00000033018.5
    Conserved Domains (3) summary
    smart00164
    Location:757 → 974
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01269
    Location:35 → 236
    PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
    pfam11830
    Location:655 → 705
    DUF3350; Domain of unknown function (DUF3350)

  7. XM_006251007.4 → XP_006251069.1  TBC1 domain family member 1 isoform X7

    See identical proteins and their annotated locations for XP_006251069.1

    UniProtKB/TrEMBL
    A0A8I5ZLK4
    Conserved Domains (3) summary
    smart00164
    Location:661 → 878
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01269
    Location:43 → 140
    PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
    pfam11830
    Location:559 → 609
    DUF3350; Domain of unknown function (DUF3350)

  8. XM_063273344.1 → XP_063129414.1  TBC1 domain family member 1 isoform X8

Nucleotide Protein Strain
Heading Accession and Version

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