Man2b2 mannosidase, alpha, class 2B, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Man2b2provided by RGD
Official Full Name: mannosidase, alpha, class 2B, member 2provided by RGD
Primary source: RGD:1308840
See related: Ensembl:ENSRNOG00000056162 AllianceGenome:RGD:1308840
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ab2-450
Summary: Enables alpha-mannosidase activity. Involved in mannose metabolic process. Located in lysosome. Orthologous to human MAN2B2 (mannosidase alpha class 2B member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 156.5), Spleen (RPKM 134.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (78193797..78218802)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (73969079..73994089)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (78939959..78964961)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH136865 (e-PCR)
- UniSTS:218954

AU048890 (e-PCR)
- UniSTS:145340

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-mannosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-mannosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mannose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in oligosaccharide catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: epididymis-specific alpha-mannosidase

Names: mannosidase 2, alpha B2

NP_001128443.2

EC 3.2.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134971.4 → NP_001128443.2 epididymis-specific alpha-mannosidase precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

B5DEJ3

Related

ENSRNOP00000074589.2, ENSRNOT00000078562.2

Conserved Domains (2) summary

PLN02701
Location:27 → 792

PLN02701; alpha-mannosidase

cd10811
Location:27 → 352

GH38N_AMII_Epman_like; N-terminal catalytic domain of mammalian core-specific lysosomal alpha 1,6-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)