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Tacc3 transforming, acidic coiled-coil containing protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360962, updated on 13-Apr-2024

Summary

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Official Symbol
Tacc3provided by RGD
Official Full Name
transforming, acidic coiled-coil containing protein 3provided by RGD
Primary source
RGD:1302948
See related
Ensembl:ENSRNOG00000017259 AllianceGenome:RGD:1302948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in Thymus (RPKM 221.5), Spleen (RPKM 155.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tacc3 in Genome Data Viewer
Location:
14q21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81275755..81289894, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77051209..77065343, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (82336283..82350069, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor 3 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA18 Neighboring gene transmembrane protein 129, E3 ubiquitin ligase Neighboring gene stem-loop histone mRNA binding protein Neighboring gene family with sequence similarity 53, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. Cheeseman LP, et al. J Cell Sci, 2013 May 1. PMID 23532825, Free PMC Article
  2. TACC3 expression and localization in the murine egg and ovary. Hao Z, et al. Mol Reprod Dev, 2002 Nov. PMID 12237944
  3. The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. Piekorz RP, et al. EMBO J, 2002 Feb 15. PMID 11847113, Free PMC Article
  4. A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. Booth DG, et al. EMBO J, 2011 Mar 2. PMID 21297582, Free PMC Article
  5. Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development. Sadek CM, et al. Mech Dev, 2000 Oct. PMID 11025203

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within astral microtubule organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebral cortex development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cerebral cortex development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within interkinetic nuclear migration ISO
Inferred from Sequence Orthology
more info
  
involved_in metaphase/anaphase transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization involved in mitosis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transforming acidic coiled-coil-containing protein 3
Names
transforming acidic coiled coil 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004424.3 → NP_001004424.3  transforming acidic coiled-coil-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I5ZK91, A0A8I6ATD8
    Related
    ENSRNOP00000097835.1, ENSRNOT00000103703.1
    Conserved Domains (2) summary
    PHA03247
    Location:137 → 381
    PHA03247; large tegument protein UL36; Provisional
    pfam05010
    Location:387 → 580
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    81275755..81289894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251329.4 → XP_006251391.2  transforming acidic coiled-coil-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y652, A0A8I5ZK91
    Related
    ENSRNOP00000076588.1
    Conserved Domains (2) summary
    PHA03247
    Location:248 → 492
    PHA03247; large tegument protein UL36; Provisional
    pfam05010
    Location:498 → 691
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  2. XM_006251330.5 → XP_006251392.2  transforming acidic coiled-coil-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    D3Z962
    Conserved Domains (2) summary
    PRK03427
    Location:263 → 371
    PRK03427; cell division protein ZipA; Provisional
    pfam05010
    Location:498 → 616
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

  3. XM_063273388.1 → XP_063129458.1  transforming acidic coiled-coil-containing protein 3 isoform X3

  4. XM_039092209.2 → XP_038948137.1  transforming acidic coiled-coil-containing protein 3 isoform X4

    Conserved Domains (1) summary
    NF033804
    Location:261 → 389
    Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin
Nucleotide Protein Strain
Heading Accession and Version

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