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Rpp14 ribonuclease P/MRP subunit p14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361020, updated on 2-May-2024

Summary

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Symbol
Rpp14provided by RGD
Full Name
ribonuclease P/MRP subunit p14provided by RGD
Primary source
RGD:1305436
See related
Ensembl:ENSRNOG00000039829 AllianceGenome:RGD:1305436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be located in nucleolus. Predicted to be part of multimeric ribonuclease P complex. Orthologous to human RPP14 (ribonuclease P/MRP subunit p14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 141.1), Thymus (RPKM 115.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rpp14 in Genome Data Viewer
Location:
15p14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (19268025..19278216, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (16837796..16847970, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (18625963..18636157, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase E1 subunit beta Neighboring gene PX domain containing serine/threonine kinase Neighboring gene abhydrolase domain containing 6, acylglycerol lipase Neighboring gene deoxyribonuclease 1L3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P. Jarrous N, et al. J Cell Biol, 1999 Aug 9. PMID 10444065, Free PMC Article
  2. Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects. Lai LB, et al. FEBS Lett, 2010 Jan 21. PMID 19931535, Free PMC Article
  3. Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes. Andreev DE, et al. Genome Biol, 2015 May 6. PMID 25943107, Free PMC Article
  4. Differential association of protein subunits with the human RNase MRP and RNase P complexes. Welting TJ, et al. RNA, 2006 Jul. PMID 16723659, Free PMC Article
  5. Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Wu J, et al. Cell, 2018 Nov 15. PMID 30454648

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hydro-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonuclease P RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease P RNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ribonuclease P activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA 5'-leader removal ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of multimeric ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of multimeric ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribonuclease P protein subunit p14
Names
ribonuclease P 14 subunit homolog
ribonuclease P 14kDa subunit
ribonuclease P/MRP 14 subunit
NP_001101842.2
NP_001135401.1
XP_008768774.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108372.3 → NP_001101842.2  ribonuclease P protein subunit p14

    See identical proteins and their annotated locations for NP_001101842.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    D4A157
    Conserved Domains (1) summary
    pfam01900
    Location:28 → 106
    RNase_P_Rpp14; Rpp14/Pop5 family

  2. NM_001141929.2 → NP_001135401.1  ribonuclease P protein subunit p14

    See identical proteins and their annotated locations for NP_001135401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    D4A157
    Related
    ENSRNOP00000057838.2, ENSRNOT00000061123.5
    Conserved Domains (1) summary
    pfam01900
    Location:28 → 106
    RNase_P_Rpp14; Rpp14/Pop5 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    19268025..19278216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008770552.4 → XP_008768774.1  ribonuclease P protein subunit p14 isoform X1

    See identical proteins and their annotated locations for XP_008768774.1

    UniProtKB/TrEMBL
    D4A157
    Conserved Domains (1) summary
    pfam01900
    Location:28 → 106
    RNase_P_Rpp14; Rpp14/Pop5 family
Nucleotide Protein Strain
Heading Accession and Version

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