Stk24 serine/threonine kinase 24 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stk24provided by RGD
Official Full Name: serine/threonine kinase 24provided by RGD
Primary source: RGD:1561742
See related: Ensembl:ENSRNOG00000011511 AllianceGenome:RGD:1561742
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MST-3; Mst3b; RGD1561742
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of axon regeneration. Located in Golgi membrane. Orthologous to human STK24 (serine/threonine kinase 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 299.8), Thymus (RPKM 238.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q24

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (104770556..104866524, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (98363707..98458940, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (106629258..106678917, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This is the first study reporting that MST3, a Ste20-like kinase, exerts a conserved regulatory role in sodium homeostasis after high-salt diet and in the development of hypertension.
Title: MST3 (mammalian Ste20-like protein kinase 3), a novel gene involved in ion homeostasis and renal regulation of blood pressure in spontaneous hypertensive rats.
Mst3b was identified as a powerful regulator for promoting spinal cord injury recovery.
Title: Mst3b promotes spinal cord neuronal regeneration by promoting growth cone branching out in spinal cord injury rats.
mechanism of regulation of MST3
Title: A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3).
Mst3b, a neuron-specific homolog of the yeast kinase Ste20, is critical for axon outgrowth. Mst3b is activated in response to trophic factors, and suppressing its expression
Title: Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth.

Submit: New GeneRIF Correction

General gene information

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Markers

RH48488 (e-PCR)
- UniSTS:57654

RH136890 (e-PCR)
- UniSTS:218979

RH129322 (e-PCR)
- UniSTS:212629

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axon regeneration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
part_of FAR/SIN/STRIPAK complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein kinase 24

Names: STE20-like kinase MST3; mammalian STE20-like protein kinase 3; serine/threonine kinase 24 (STE20 homolog, yeast)

NP_001120966.1

EC 2.7.11.1

XP_038949467.2

EC 2.7.11.1

XP_063130540.1

EC 2.7.11.1

XP_063130541.1

EC 2.7.11.1

XP_063130542.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127494.1 → NP_001120966.1 serine/threonine-protein kinase 24

See identical proteins and their annotated locations for NP_001120966.1

Status: PROVISIONAL

Source sequence(s)

EU371958

UniProtKB/Swiss-Prot

B0LT89, F1LML1

UniProtKB/TrEMBL

A0A8I5ZTB6

Related

ENSRNOP00000078151.1, ENSRNOT00000118392.1

Conserved Domains (1) summary

cd06609
Location:22 → 295

STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

104770556..104866524 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274471.1 → XP_063130541.1 serine/threonine-protein kinase 24 isoform X2

UniProtKB/TrEMBL

A6HUK1
XM_063274470.1 → XP_063130540.1 serine/threonine-protein kinase 24 isoform X2

UniProtKB/TrEMBL

A6HUK1
XM_039093539.2 → XP_038949467.2 serine/threonine-protein kinase 24 isoform X1
XM_063274472.1 → XP_063130542.1 serine/threonine-protein kinase 24 isoform X2

UniProtKB/TrEMBL

A6HUK1