Tfdp1 transcription factor Dp-1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tfdp1provided by RGD
Official Full Name: transcription factor Dp-1provided by RGD
Primary source: RGD:1560344
See related: Ensembl:ENSRNOG00000019222 AllianceGenome:RGD:1560344
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Predicted to contribute to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation of fat cell proliferation; positive regulation of G1/S transition of mitotic cell cycle; and regulation of transcription, DNA-templated. Predicted to act upstream of or within anoikis; epidermis development; and regulation of cellular macromolecule biosynthetic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to several human genes including TFDP1 (transcription factor Dp-1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 213.1), Spleen (RPKM 176.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (82864220..82903166, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (76162040..76200871, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (81088642..81127244)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anoikis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermis development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of Rb-E2F complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor Dp-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025718.1 → NP_001020889.1 transcription factor Dp-1

See identical proteins and their annotated locations for NP_001020889.1

Status: PROVISIONAL

Source sequence(s)

BC098789

UniProtKB/TrEMBL

Q4KM53

Conserved Domains (3) summary

cd14458
Location:78 → 124

DP_DD; coiled coil [structural motif]

pfam02319
Location:1 → 73

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:80 → 219

DP; Transcription factor DP

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

82864220..82903166 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094677.2 → XP_038950605.1 transcription factor Dp-1 isoform X1

UniProtKB/TrEMBL

A0A0G2JXN0, A6IWH7, G3V8H9

Related

ENSRNOP00000026150.6

Conserved Domains (3) summary

cd14458
Location:198 → 244

DP_DD; coiled coil [structural motif]

pfam02319
Location:113 → 193

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:200 → 338

DP; Transcription factor DP
XM_039094682.2 → XP_038950610.1 transcription factor Dp-1 isoform X2

UniProtKB/TrEMBL

A0A8I6GIG6, A6IWH8

Conserved Domains (3) summary

cd14458
Location:78 → 124

DP_DD; coiled coil [structural motif]

pfam02319
Location:1 → 73

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:80 → 218

DP; Transcription factor DP
XM_039094676.2 → XP_038950604.1 transcription factor Dp-1 isoform X1

UniProtKB/TrEMBL

A0A0G2JXN0, A6IWH7, G3V8H9

Related

ENSRNOP00000070337.1

Conserved Domains (3) summary

cd14458
Location:198 → 244

DP_DD; coiled coil [structural motif]

pfam02319
Location:113 → 193

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:200 → 338

DP; Transcription factor DP
XM_008771398.4 → XP_008769620.1 transcription factor Dp-1 isoform X1

See identical proteins and their annotated locations for XP_008769620.1

UniProtKB/TrEMBL

A0A0G2JXN0, A6IWH7, G3V8H9

Conserved Domains (3) summary

cd14458
Location:198 → 244

DP_DD; coiled coil [structural motif]

pfam02319
Location:113 → 193

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:200 → 338

DP; Transcription factor DP
XM_008771397.4 → XP_008769619.1 transcription factor Dp-1 isoform X1

See identical proteins and their annotated locations for XP_008769619.1

UniProtKB/TrEMBL

A0A0G2JXN0, A6IWH7, G3V8H9

Conserved Domains (3) summary

cd14458
Location:198 → 244

DP_DD; coiled coil [structural motif]

pfam02319
Location:113 → 193

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:200 → 338

DP; Transcription factor DP
XM_063275572.1 → XP_063131642.1 transcription factor Dp-1 isoform X2

UniProtKB/TrEMBL

A0A8I6GIG6, A6IWH8
XM_063275573.1 → XP_063131643.1 transcription factor Dp-1 isoform X2

UniProtKB/TrEMBL

A0A8I6GIG6, A6IWH8