U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Elmo1 engulfment and cell motility 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361251, updated on 4-May-2024

Summary

Go to the top of the page Help
Official Symbol
Elmo1provided by RGD
Official Full Name
engulfment and cell motility 1provided by RGD
Primary source
RGD:1308182
See related
Ensembl:ENSRNOG00000059705 AllianceGenome:RGD:1308182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ELMO1s
Summary
Predicted to enable SH3 domain binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including Rac protein signal transduction; actin filament organization; and phagocytosis, engulfment. Predicted to act upstream of or within actin filament-based process and phagocytosis. Predicted to be located in cytoplasm. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in plasma membrane. Orthologous to human ELMO1 (engulfment and cell motility 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 88.0), Spleen (RPKM 74.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17q11
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (48982188..49518525, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (44286495..44822668, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (46352102..46888788, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 11 Neighboring gene FUS RNA binding protein, pseudogene 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene keratin 18, pseudogene 6 Neighboring gene G protein-coupled receptor 141

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons. Blazejczyk M, et al. Mol Neurobiol, 2017 May. PMID 26993296, Free PMC Article
  2. The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons. Kim JY, et al. J Biol Chem, 2011 Oct 28. PMID 21900250, Free PMC Article
  3. ELMO1 increases expression of extracellular matrix proteins and inhibits cell adhesion to ECMs. Shimazaki A, et al. Kidney Int, 2006 Nov. PMID 17021600
  4. Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. Li W, et al. J Biol Chem, 2018 May 18. PMID 29615491, Free PMC Article
  5. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Brugnera E, et al. Nat Cell Biol, 2002 Aug. PMID 12134158

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. prolonged overexpression of Elmo1 in cultured hippocampal neurons increased axonal growth, decreased dendritic spine density, and affected their shape.
    Title: Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons.
  2. The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.
    Title: The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.
  3. Cell adhesion to extracellular matrix proteins was considerably inhibited in cells overexpressing ELMO1. This suggest that ELMO1 contributes to the development and progression of chronic glomerular injury.
    Title: ELMO1 increases expression of extracellular matrix proteins and inhibits cell adhesion to ECMs.
  4. RhoG activates Rac1 through Elmo and Dock180 to control cell morphology.
    Title: RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin filament-based process ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell motility ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of guanyl-nucleotide exchange factor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
engulfment and cell motility protein 1
Names
engulfment and cell motility 1 splice 1
engulfment and cell motility 1, ced-12 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395578.1 → NP_001382507.1  engulfment and cell motility protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6KN57, D3ZY46
    Related
    ENSRNOP00000073757.2, ENSRNOT00000090663.2
    Conserved Domains (3) summary
    cd13359
    Location:546 → 675
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:303 → 481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 279
    DUF3361; Domain of unknown function (DUF3361)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    48982188..49518525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276615.1 → XP_063132685.1  engulfment and cell motility protein 1 isoform X2

    UniProtKB/TrEMBL
    A6KN57

  2. XM_063276610.1 → XP_063132680.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/TrEMBL
    G8CYZ7

  3. XM_063276616.1 → XP_063132686.1  engulfment and cell motility protein 1 isoform X2

    UniProtKB/TrEMBL
    A6KN57

  4. XM_063276611.1 → XP_063132681.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/TrEMBL
    G8CYZ7

  5. XM_063276609.1 → XP_063132679.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/TrEMBL
    G8CYZ7

  6. XM_063276614.1 → XP_063132684.1  engulfment and cell motility protein 1 isoform X2

    UniProtKB/TrEMBL
    A6KN57

  7. XM_063276612.1 → XP_063132682.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/TrEMBL
    G8CYZ7

RNA

  1. XR_010058900.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108415.1: Suppressed sequence

    Description
    NM_001108415.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous