Asb13 ankyrin repeat and SOCS box-containing 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asb13provided by RGD
Official Full Name: ankyrin repeat and SOCS box-containing 13provided by RGD
Primary source: RGD:1310387
See related: Ensembl:ENSRNOG00000017967 AllianceGenome:RGD:1310387
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB13 (ankyrin repeat and SOCS box containing 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 246.8), Testes (RPKM 221.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (71474531..71493238, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (66564653..66583365, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (70215401..70234103, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE106817 (e-PCR)
- UniSTS:261650

BE113707 (e-PCR)
- UniSTS:246775

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ankyrin repeat and SOCS box protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108420.1 → NP_001101890.1 ankyrin repeat and SOCS box protein 13

See identical proteins and their annotated locations for NP_001101890.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I5ZVB3, A6JLQ6, D3ZEJ6

Related

ENSRNOP00000024200.2, ENSRNOT00000024200.4

Conserved Domains (5) summary

cd00204
Location:46 → 170

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd03729
Location:237 → 278

SOCS_ASB13; SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...

pfam12796
Location:56 → 147

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:19 → 72

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:119 → 147

ANK; ANK repeat [structural motif]