U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Msrb2 methionine sulfoxide reductase B2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361286, updated on 17-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Msrb2provided by RGD
Official Full Name
methionine sulfoxide reductase B2provided by RGD
Primary source
RGD:1306026
See related
Ensembl:ENSRNOG00000016873 AllianceGenome:RGD:1306026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mrsb
Summary
Predicted to enable actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Predicted to be involved in actin filament polymerization. Predicted to act upstream of or within protein repair. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Orthologous to human MSRB2 (methionine sulfoxide reductase B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 136.5), Adrenal (RPKM 131.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Msrb2 in Genome Data Viewer
Location:
17q12.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (86882750..86908392)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (81974378..82000044)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (86066841..86148131)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 3 Neighboring gene PICALM interacting mitotic regulator like 1 Neighboring gene uncharacterized LOC102556079 Neighboring gene uncharacterized LOC134482617 Neighboring gene similar to human chromosome 10 open reading frame 67 Neighboring gene pancreas associated transcription factor 1a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Lee BC, et al. Mol Cell, 2013 Aug 8. PMID 23911929, Free PMC Article
  2. Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. Kim HY, et al. Mol Biol Cell, 2004 Mar. PMID 14699060, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC114588

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-methionine-(R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide-methionine (R)-S-oxide reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide-methionine (R)-S-oxide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein repair ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
methionine-R-sulfoxide reductase B2, mitochondrial
NP_001026830.1
XP_038951891.1
XP_038951892.1
XP_063132729.1
XP_063132730.1
XP_063132731.1
XP_063132732.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031660.2 → NP_001026830.1  methionine-R-sulfoxide reductase B2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001026830.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    Q4FZX5
    UniProtKB/TrEMBL
    A6JMA1
    Related
    ENSRNOP00000022661.4, ENSRNOT00000022661.7
    Conserved Domains (1) summary
    cl15841
    Location:42 → 171
    SelR; SelR domain

  2. NM_001429284.1 → NP_001416213.1  methionine-R-sulfoxide reductase B2, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017

  3. NM_001429285.1 → NP_001416214.1  methionine-R-sulfoxide reductase B2, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    86882750..86908392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276662.1 → XP_063132732.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X2

  2. XM_039095964.2 → XP_038951892.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl15841
    Location:42 → 91
    SelR; SelR domain

  3. XM_063276661.1 → XP_063132731.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X1

  4. XM_063276660.1 → XP_063132730.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X1

  5. XM_063276659.1 → XP_063132729.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X1

  6. XM_039095963.2 → XP_038951891.1  methionine-R-sulfoxide reductase B2, mitochondrial isoform X3

    Conserved Domains (1) summary
    pfam01641
    Location:2 → 102
    SelR; SelR domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4FZX5.1 GenPept UniProtKB/Swiss-Prot:Q4FZX5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous