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Mocos molybdenum cofactor sulfurase [ Rattus norvegicus (Norway rat) ]

Gene ID: 361300, updated on 13-Apr-2024

Summary

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Official Symbol
Mocosprovided by RGD
Official Full Name
molybdenum cofactor sulfuraseprovided by RGD
Primary source
RGD:1308496
See related
Ensembl:ENSRNOG00000015113 AllianceGenome:RGD:1308496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable Mo-molybdopterin cofactor sulfurase activity. Predicted to be involved in molybdopterin cofactor metabolic process. Human ortholog(s) of this gene implicated in xanthinuria. Orthologous to human MOCOS (molybdenum cofactor sulfurase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 48.3), Lung (RPKM 38.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18p12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (16206402..16251928)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (15931659..15977415)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (16590086..16636312)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 6 Neighboring gene elongator acetyltransferase complex subunit 2 Neighboring gene formin homology 2 domain containing 3 Neighboring gene uncharacterized LOC120098112 Neighboring gene heat shock cognate protein 70, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II. Ichida K, et al. Biochem Biophys Res Commun, 2001 Apr 20. PMID 11302742
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Mo-molybdopterin cofactor sulfurase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Mo-molybdopterin cofactor sulfurase activity ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables molybdenum cofactor sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables molybdenum ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in molybdopterin cofactor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in molybdopterin cofactor metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in molybdopterin cofactor metabolic process ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
molybdenum cofactor sulfurase
NP_001382600.1
XP_017456477.1
XP_063133533.1
XP_063133534.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395671.1 → NP_001382600.1  molybdenum cofactor sulfurase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A1W2Q693, A6J2K9
    Related
    ENSRNOP00000076171.1, ENSRNOT00000093715.2
    Conserved Domains (1) summary
    PLN02724
    Location:28 → 854
    PLN02724; Molybdenum cofactor sulfurase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    16206402..16251928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277464.1 → XP_063133534.1  molybdenum cofactor sulfurase isoform X2

  2. XM_063277463.1 → XP_063133533.1  molybdenum cofactor sulfurase isoform X1

  3. XM_017600988.3 → XP_017456477.1  molybdenum cofactor sulfurase isoform X3

RNA

  1. XR_001842027.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108425.1: Suppressed sequence

    Description
    NM_001108425.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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